Spectrum and presentation of pediatric malignancies in the HIV era: Experience from Blantyre, Malawi, 1998-2003
Spectrum and presentation of pediatric malignancies in the HIV era: Experience from Blantyre, Malawi, 1998-2003
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DOI：
10.1002/pbc.20917
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发表时间：
2007-05-01
影响因子：
3.2
通讯作者：
Liomba, G.
中科院分区：
文献类型：
--
作者：
Sinfield, R. L.;Molyneux, E. M.;Liomba, G.
关于非洲儿童癌症的数据很少，特别是自从艾滋病毒传播以来。我们的目的是记录马拉维一家大型中心医院儿科癌症的发生频率，详细介绍这些儿童的表现特征，初步调查和艾滋病毒状况。Procedure.回顾性审查1998年至2003年期间在伊丽莎白女王中央医院（QECH）就诊的儿童（< 16岁）癌症谱和临床表现。结果707名儿童患有癌症，每年的病例数随着时间的推移而增加; 50%（351）患有伯基特淋巴瘤，13%（89）患有视网膜母细胞瘤，9%（61）患有卡波西肉瘤，其余为各种其他肿瘤。卡波西肉瘤的发生率随时间显著增加。49%（348）的患者可获得诊断的组织学验证。接受艾滋病毒检测的癌症儿童比例随着时间的推移而增加，但因癌症类型而异。在这些受试者中，卡波西肉瘤儿童的血清阳性率为93%（52/56），伯基特淋巴瘤为4%（11/289），其他非霍奇金淋巴瘤为31%（8/26），霍奇金病为7%（1/15），其他癌症为5%（5/103）。结论.在研究期间，几乎所有癌症，尤其是卡波西肉瘤，每年的病例数都有所增加。伯基特淋巴瘤仍然是马拉维最常见的儿科肿瘤。在伯基特淋巴瘤，非霍奇金淋巴瘤，卡波西肉瘤的情况下，有一个显着的差异，在介绍艾滋病毒血清阳性和血清阴性儿童。
Background Data on childhood cancers in Africa are sparse, particularly since the spread of HIV. We aimed to document the frequency of pediatric cancers presenting to a large central hospital in Malawi, detailing the presenting features, initial investigations, and HIV status of these children. Procedure. A retrospective audit of the spectrum and clinical presentation of cancers among children (< 16 years) seen at Queen Elizabeth's Central Hospital (QECH), between 1998 and 2003. Results. Seven hundred seven children with cancer were seen, the number of cases per year increased over the time period; 50% (351) had Burkitt lymphoma, 13% (89) had retinoblastoma, and 9% (61) had Kaposi sarcoma, with a variety of other tumors comprising the remainder. Kaposi sarcoma markedly increased in frequency over time. Histological verification of diagnosis was available for 49% (348). The proportion of children with cancer who were tested for HIV increased over time, but varied by cancer type. Amongst those tested, the seroprevalence was 93% (52/56) for children with Kaposi sarcoma, 4% (11/289) for those with Burkitt lymphoma, 31% (8/26) for those with other nonHodgkin lymphomas, 7% (1/15) for those with Hodgkin disease, and 5% (5/103) for those with other cancers. Conclusions. The number of cases seen per year has increased over the study period for almost all cancers, hut in particular for Kaposi sarcoma. Burkitt lymphoma remains the commonest pediatric tumor in Malawi. In the case of Burkitt lymphoma, non-Hodgkin lymphoma, and Kaposi sarcoma there is a significant difference in the presentation of HIV-seropositive and -seronegative children.