Glucocorticoid therapy for rheumatic diseases.
Glucocorticoid therapy for rheumatic diseases.
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糖皮质激素治疗风湿性疾病。
DOI：
10.1097/00002281-199206000-00007
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发表时间：
1992
影响因子：
5.1
通讯作者：
Kimberly,RP
中科院分区：
文献类型：
--
作者：
Kimberly,RP
糖皮质激素是治疗许多炎症、自身免疫性疾病和其他风湿性疾病必不可少的治疗药物。也许是因为其显著的效力和广泛的使用，关于类固醇治疗的文献往往是相当轶事。尽管如此，新的信息，无论是作用机制和临床应用，继续成为可用的。类固醇受体参与和基因调控的生物学复杂性正在解开，精心设计的临床研究正在帮助完善临床应用。然而，对于临床医生来说，仔细观察和合理判断糖皮质激素的使用仍然是至关重要的。
Glucocorticoids are an essential therapeutic agent in the management of many inflammatory, autoimmune, and other rheumatic diseases. Perhaps because of their remarkable potency and widespread use, the literature on steroid treatment has tended to be rather anecdotal. Nonetheless, new information, both on the mechanism of action and on the clinical application, continues to become available. The complexity of the biology of steroid-receptor engagement and gene regulation is unraveling, and carefully designed clinical studies are helping to refine clinical application. However, for the clinician, the need for careful observation and sound judgment with glucocorticoid use remains critically important.