Human symbionts use a host-like pathway for surface fucosylation
Human symbionts use a host-like pathway for surface fucosylation
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DOI：
10.1126/science.1106469
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发表时间：
2005-03-18
期刊：
影响因子：
56.9
通讯作者：
Comstock, LE
中科院分区：
文献类型：
--
作者：
Coyne, MJ;Reinap, B;Comstock, LE
哺乳动物的肠道中含有有益的微生物区系，每克结肠内容物约有10(12)个微生物。宿主能忍受这种巨大的细菌。负载，同时保持对病原体有效反应的能力。在本研究中，我们发现类杆菌通过一种类似哺乳动物的途径，将大量的表面被膜多糖和糖蛋白与L岩藻糖修饰，这是一种丰富的肠上皮细胞表面分子，导致宿主和共生体协调表达这一表面分子。类杆菌突变体缺乏用L岩藻糖覆盖其表面的能力，在竞争条件下在哺乳动物肠道的定植是有缺陷的。
The mammalian intestine harbors a beneficial microbiota numbering approximately 10(12) organisms per gram of colonic content. The host tolerates this tremendous bacterial. load while maintaining the ability to efficiently respond to pathogenic organisms. In this study, we show that the Bacteroides use a mammalian-like pathway to decorate numerous surface capsular polysaccharides and glycoproteins with L-fucose, an abundant surface molecule of intestinal epithelial cells, resulting in the coordinated expression of this surface molecule by host and symbiont. A Bacteroides mutant deficient in the ability to cover its surface with L-fucose is defective in colonizing the mammalian intestine under competitive conditions.