Higher clearance of hepatitis C virus infection in females compared with males
Higher clearance of hepatitis C virus infection in females compared with males
复制标题
DOI：
10.1136/gut.2006.078147
复制
发表时间：
2006-08-01
期刊：
影响因子：
24.5
通讯作者：
Fontanet, A.
中科院分区：
文献类型：
--
作者：
Bakr, I.;Rekacewicz, C.;Fontanet, A.
背景和目的：据文献报道，14-46%的受试者在感染丙型肝炎病毒后可从血液中清除丙型肝炎病毒。关于丙型肝炎病毒清除率的性别差异存在争议。患者和方法：我们使用埃及大规模人群丙型肝炎病毒感染研究的数据，比较了男性和女性的丙型肝炎病毒清除率。本文使用的定义为：清除的丙型肝炎病毒感染(丙型肝炎病毒抗体阳性，丙型肝炎病毒RNA检测结果阴性)和慢性丙型肝炎病毒感染(丙型肝炎病毒抗体阳性，丙型肝炎病毒RNA检测结果阳性)。调查对象为4720名18~65岁农村居民，调查对象为家庭访谈者(n=2425)和自愿筛查者(n=2295)。结果：调查对象的丙型肝炎病毒抗体总感染率为910/4720(19.3%，95%可信区间18.2~20.4)。在910例丙型肝炎抗体阳性者中，61.5%有慢性丙型肝炎病毒感染。与男性相比，女性更有可能清除病毒(分别为44.6%和33.7%；p=0.001)。控制年龄、血吸虫病病史、医源性暴露和性接触丙型肝炎病毒并没有改变女性与病毒清除之间的正相关。结论：这项研究提供了强有力的证据支持女性比男性更高的丙型肝炎病毒清除率。
Background and aims: According to the literature, 14 - 46% of subjects clear hepatitis C virus (HCV) from blood after infection. Controversy exists about sex differences in HCV clearance rates.Patients and methods: We compared HCV clearance in males and females using data from a large population based study on HCV infection in Egypt. Definitions used in the paper were: cleared HCV infection (positive HCV antibody and negative HCV RNA test results) and chronic HCV infection (positive HCV antibody and positive HCV RNA test results). The study sample included 4720 village residents aged 18 - 65 years recruited through home based visits (n = 2425) or voluntary screening (n = 2295).Results: Overall, HCV antibody prevalence was 910/4720 (19.3% (95% confidence interval 18.2 - 20.4)). Of those with HCV antibodies (n = 910), 61.5% had chronic HCV infection. Compared with males, females were more likely to have cleared the virus (44.6% v 33.7%, respectively; p = 0.001). Control for age, schistosomiasis history, iatrogenic exposures, and sexual exposure to HCV did not alter the positive association between female sex and viral clearance.Conclusion: This study provides strong evidence in favour of a higher HCV clearance rate in females compared with males.