(Pentamethylcyclopentadienyl)cobalt(III)-Catalyzed Oxidative [4+2] Annulation of N-H Imines with Alkynes: Straightforward Synthesis of Multisubstituted Isoquinolines
(Pentamethylcyclopentadienyl)cobalt(III)-Catalyzed Oxidative [4+2] Annulation of N-H Imines with Alkynes: Straightforward Synthesis of Multisubstituted Isoquinolines
复制标题
(五甲基环戊二烯基)钴(III)催化氧化[4 2] N-H亚胺与炔烃的环化：多取代异喹啉的直接合成
DOI：
10.1002/adsc.201600025
复制
发表时间：
2016
影响因子：
5.4
通讯作者：
Wang Honggen
中科院分区：
文献类型：
--
作者：
Zhang Shang-Shi;Liu Xu-Ge;Chen Shi-Yong;Tan Dong-Hang;Jiang Chun-Yong;Wu Jia-Qiang;Li Qingjiang;Wang Honggen
介绍了在高价五甲基钴[Cp*Co（III）]催化下，N-巯基亚胺与炔[4+2]环合合成异喹啉的方法。发现硫酸铈（IV）是代替常用的铜盐或银盐的有效氧化剂。观察到宽的底物范围、高官能团耐受性和一般良好的产率。
A synthetic method for isoquinoline synthesisviaa [4+2] annulation of NH imines with alkynes using the high‐valent (pentamethylcyclopentadienyl)cobalt(III) [Cp*Co(III)] catalyst is described. Cerium(IV) sulfate was found to be an efficient oxidant in lieu of the commonly used copper or silver salts. Broad substrate scope, high functional group tolerance, and generally good yields were observed.