A contribution to the theory of permeability of thin films
A contribution to the theory of permeability of thin films
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DOI：
10.1002/jcp.1030050409
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发表时间：
1935-02-01
影响因子：
--
通讯作者：
Davson, H
中科院分区：
文献类型：
--
作者：
Danielli, JF;Davson, H
本文提出了一种细胞表面模型，它由一层很薄的类脂膜和一层吸附在其上的蛋白质膜组成，假定（1）类脂分子与已知的类脂分子相似，（2）类脂中既有酸性基团又有碱性基团，（3）类脂层上吸附着一层来自细胞内容物的蛋白质分子。吸附的蛋白质膜将形成具有高度水合间隙的不可渗透区域的马赛克，因此可以基于分子大小显示对不带电荷的非脂质的选择性渗透性。膜上的电荷将决定离子的渗透性。水（和水溶性物质）的通过速率将由膜中单价盐与多价盐的比例决定。如果Ca++增加到一个临界点，薄膜就会破裂，渗透性会突然不可逆地增加。低渗溶液中红细胞的Hb突然丢失被引用作为这种现象的例子。具有更易溶解的盐的离子将倾向于增加对水的渗透性，反之亦然。高温。推导出渗透速率系数，其不涉及作为渗透机理的一部分的化学反应。
A model for the cell surface is suggested, consisting of a very thin lipoid film with a protein film adsorbed on it. It is assumed that (1) the lipoid molecules are similar to known lipoids, (2) there will be both acidic and basic groups active in the lipoid and (3) a layer of protein molecules is adsorbed on the lipoid layer from the cell contents. The adsorbed protein film will make a mosaic of impenetrable areas with heavily hydrated interspaces, and thus can show selective permeability toward un-charged non-lipoids based on molecular size. The charge on the film will determine the penetrability of ions. The rate of passage of water (and water soluble substances) will be determined by the proportion of monovalent salts to polyvalent salts in the membrane. If Ca++ increases to a critical point the film breaks down and there is a sudden irreversible increase in permeability. The sudden loss of Hb by erythrocytes in hypotonic solutions is cited as example of this phenomenon. The ion having the more soluble salt will tend to increase permeability to water, and vice versa. A high temp. coefficient for the rate of penetration is deduced which does not involve a chemical reaction as part of the mechanism of penetration.