Blocking IL-10 signalling at the time of immunization renders the tumour more accessible to T cell infiltration in mice
Blocking IL-10 signalling at the time of immunization renders the tumour more accessible to T cell infiltration in mice
复制标题
在免疫时阻断 IL-10 信号传导使小鼠体内的肿瘤更容易被 T 细胞浸润。
DOI：
10.1016/j.cellimm.2015.11.002
复制
发表时间：
2016-02-01
影响因子：
4.3
通讯作者：
Liu, Xiaosong
中科院分区：
文献类型：
--
作者：
Chen, Shu;Ni, Guoying;Liu, Xiaosong
我们最近报道，在人乳头瘤病毒（HPV）长E7肽/LPS免疫时阻断IL-10信号可导致小鼠中已建立的HPV-16永生化肿瘤的消退，类似于长E7肽/不完全弗氏佐剂（IFA）疫苗诱导的肿瘤消退。在本文中，我们证明了在长E7肽/LPS时阻断IL-10信号可以引起更强的T细胞反应，并使肿瘤更容易被免疫细胞浸润，而不是接种长E7肽/IFA。此外，与长E7肽/IFA免疫相比，用长E7肽/LPS和IL10信号阻断剂启动，然后用长E7肽/IFA免疫增强，可引起更强的CD8+ T细胞反应。结果表明，在临床应用长E7肽/LPS和IL10信号抑制剂，然后用长E7肽/IFA诱导物增强，可能会导致HPV感染相关肿瘤更好的消退。(C) 2015爱思唯尔公司版权所有。
We recently reported that blockade of IL-10 signalling at the time of a human papillomavirus (HPV) long E7 peptide/LPS immunization leads to the regression of established HPV-16 immortalized tumours in mice similar to that induced by long E7 peptide/incomplete Freund's adjuvant (IFA)-based vaccination. In this paper, we demonstrated that blockade of IL-10 signalling at the time of long E7 peptide/LPS could elicit stronger T cells responses and render the tumour more accessible for immune cell infiltration than vaccination with long E7 peptide/IFA. Furthermore, priming with long E7 peptide/LPS and IL10 signalling blockade then boosting with long E7 peptide/IFA elicits stronger CD8+ T cell responses than long E7 peptide/IFA immunization. The results suggest that priming with long E7 peptide/LPS and IL10 signalling inhibitor, then boosting with long E7 peptide/IFA elicits may lead to better HPV infection related tumour regression in clinic. (C) 2015 Elsevier Inc. All rights reserved.