Hereditary nephropathy (Alport syndrome): correlation of clinical data with glomerular basement membrane alterations.
Hereditary nephropathy (Alport syndrome): correlation of clinical data with glomerular basement membrane alterations.
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遗传性肾病（阿尔波特综合征）：临床数据与肾小球基底膜改变的相关性。
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
Rumpelt Hj
中科院分区：
文献类型：
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作者：
Rumpelt Hj
对27个遗传性肾病（Alport综合征）家系的32例患者进行了肾小球基底膜电镜检查，并测定了特征性分裂和薄基底膜部分的百分率。男性的临床病程更严重，这与基底膜改变的发生率更高相对应：男性平均61%裂开和6%变薄，但女性仅18%裂开和21%变薄。分裂性病变随年龄增加而增加，但在女性。也有迹象表明分裂性病变与蛋白尿的分级可能呈正相关。与分裂性病变相比，基底膜变薄似乎是次要的。
: In 32 patients from 27 families affected with hereditary neophropathy (Alport syndrome) the glomerular basement membranes were examined electron microscopically and the percentage of characteristically split and thin basement membrane portions was determined. The clinical course was more severe in males which corresponded with a higher rate of basement membrane alterations: on an average in males 61% split and 6% thin but only 18% split and 21% thin in females. The splitting lesion increased with age in males but not so in females. There were also indications for a possible positive correlation of the splitting lesion and the grade of proteinuria. Compared with the splitting lesion basement membrane thinning seemed to be of minor importance.