Pathophysiology of avian intestinal ion transport.
Pathophysiology of avian intestinal ion transport.
复制标题
禽类肠道离子运输的病理生理学。
DOI：
10.1017/s004393391800003x
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Nighot,Prashant
中科院分区：
文献类型：
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作者：
Nighot,Meghali;Nighot,Prashant
肠道对于家禽生产的商业成功具有重要意义。在肠上皮细胞的顶膜和基底膜上存在大量的离子转运蛋白、交换蛋白和通道，它们在不同肠段内沿隐窝-绒毛轴的差异表达沿着确保了有效的肠吸收和有效的屏障功能。最近的研究表明，密集的生产系统，微生物暴露和营养管理显着影响肠道生理和肠道离子转运。正常肠道离子转运失调表现为腹泻、吸收不良和肠道炎症，导致生产效率低下。本文讨论了鸟类肠道离子转运的基本机制，以及生长过程中发育、营养和环境变化以及肠道微生物感染对其的影响。肠道微生物感染对鸟类肠道离子转运的影响取决于宿主免疫力、病原体毒力和特定肠段的粘膜组织等因素。
The gut has great importance for the commercial success of poultry production. Numerous ion transporters, exchangers, and channels are present on both the apical and the basolateral membrane of intestinal epithelial cells, and their differential expression along the crypt-villus axis within the various intestinal segments ensures efficient intestinal absorption and effective barrier function. Recent studies have shown that intensive production systems, microbial exposure, and nutritional management significantly affect intestinal physiology and intestinal ion transport. Dysregulation of normal intestinal ion transport is manifested as diarrhoea, malabsorption, and intestinal inflammation resulting into poor production efficiency. This review discusses the basic mechanisms involved in avian intestinal ion transport and the impact of development during growth, nutritional and environmental alterations, and intestinal microbial infections on it. The effect of intestinal microbial infections on avian intestinal ion transport depends on factors such as host immunity, pathogen virulence, and the mucosal organisation of the particular intestinal segment.