The metastatic lymph node ratio predicts survival in colon cancer
The metastatic lymph node ratio predicts survival in colon cancer
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DOI：
10.1016/j.amjsurg.2007.08.030
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发表时间：
2007-12-01
影响因子：
3
通讯作者：
Anthony, Thomas
中科院分区：
文献类型：
--
作者：
Schumacher, Paul;Dineen, Sean;Anthony, Thomas
背景：淋巴结转移是非IV期结肠癌患者最重要的生存预测因子。最近对胃癌的研究表明，淋巴结比例（阳性淋巴结数除以总淋巴结数）对预后有重要意义。我们的目的是确定淋巴结比例（LNR）是否能预测三级护理退伍军人事务医疗中心的无病生存（DFS）和总生存（OS）。方法：对前瞻性收集的结肠癌患者数据库进行回顾性分析，以确定LNR对DFS和OS的影响。232例非IV期结肠癌患者入选分析。采用Kaplan-Meier法绘制生存曲线。结果：所有患者的LNR为。08被确定为预测OS和DFS的断点。III期患者的特异性分析显示LNR为。18是预测DFS的指标。结论：这项研究显示了基于比例的结肠癌分期的预后意义，并可能有助于未来的分期系统。(c) 2007年摘录医药有限公司版权所有。
Background: Lymph node metastases are the most important predictor of survival in non-stage IV colon cancer. Recent studies of gastric cancer have shown a prognostic significance of a lymph node ratio (number of positive nodes divided by total number harvested). Our goal was to determine whether a lymph node ratio (LNR) would predict disease-free survival (DFS) and overall survival (OS) in a tertiary care Veterans Affairs medical center.Methods: A retrospective review of a prospectively collected database of colon cancer patients was performed to determine the effect of LNR on DFS and OS. A cohort of 232 patients with non-stage IV colon cancer was eligible for analysis. Survival curves were constructed using the Kaplan-Meier method.Results: For all patients, a LNR of .08 was identified as a breakpoint for predicting OS and DFS. Specific analysis of stage III patients revealed that a LNR of .18 was predictive of DFS.Conclusions: This study showed the prognostic significance of ratio-based staging for colon cancer and may aid in future staging systems. (c) 2007 Excerpta Medica Inc. All rights reserved.