Overexpression of GLUT-1 in the invasion front is associated with depth of oral squamous cell carcinoma and prognosis
Overexpression of GLUT-1 in the invasion front is associated with depth of oral squamous cell carcinoma and prognosis
复制标题
DOI：
10.1111/j.1600-0714.2009.00814.x
复制
发表时间：
2010-01-01
影响因子：
3.3
通讯作者：
Hino, Okio
中科院分区：
文献类型：
--
作者：
Ohba, Shinichi;Fujii, Hiroaki;Hino, Okio
目的：恶性肿瘤细胞对葡萄糖的摄取增加，这被认为是由葡萄糖转运蛋白（GLUTs）促进的。在许多人类癌症中已经报道了GLUT-1表达增加。方法：对24例口腔鳞癌组织中GLUT-1的表达进行分析，并与临床特征进行相关性研究。结果：所有口腔鳞癌组织中GLUT-1的表达均与肿瘤的深度有关（P = 0.023 < 0.05）。浸润前沿过表达的患者生存期明显短于GLUT-1弱阳性患者（P = 0.046 < 0.05）。GLUT-1免疫组化染色与年龄、性别、亚部位、肿瘤大小或淋巴结状态之间无显著相关性。结论：本研究表明，GLUT-1作为一种标志物，表明肿瘤浸润深度较深，由于淋巴结转移、原发灶复发或远处转移，往往导致患者预后较差。
Object:Malignant cells show increased uptake, which is considered to be facilitated by glucose transporters (GLUTs). Increased GLUT-1 expression has been reported in many human cancers. We hypothesized that a oral squamous cell carcinoma, characterized by high frequency of lymph node metastasis, distant metastasis or local recurrences, was associated with GLUT-1 overexpression in invasion front.Methods:GLUT-1 immunostaining in invasion front was studied on 24 oral squamous cell carcinomas, and revealed the correlation with the clinical characteristics.Result:The analysis showed that all oral squamous cell carcinoma patients and GLUT-1 expression correlated the depth of the tumors (P = 0.023 < 0.05). Furthermore the survival of patients who had overexpression of invasion front was significant shorter than that of patients with GLUT-1 weakly positive (P = 0.046 < 0.05). No significant association was noted between GLUT-1 immunostaining and either age, gender, subsites, tumor size, or lymph node status.Conclusion:The present study shows that GLUT-1 served as a marker indicating that tumors with deep invasion tended to result in a worse prognosis in patients due to either lymph node metastasis, a recurrence of the primary lesion or distant metastasis.