Neopterin concentrations in pediatric human immunodeficiency virus infection as predictor of disease activity.
Neopterin concentrations in pediatric human immunodeficiency virus infection as predictor of disease activity.
复制标题
儿科人类免疫缺陷病毒感染中的新蝶呤浓度作为疾病活动的预测因子。
DOI：
10.1097/00006454-199204000-00005
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Rubinstein,A
中科院分区：
文献类型：
--
作者：
Ellaurie,M;Calvelli,T;Rubinstein,A
50例人类免疫缺陷病毒感染患儿血清新喋呤浓度与病程相关。新喋呤的浓度范围为4到70 nM，平均为34.7$25.1(SD)nM，而人类免疫缺陷病毒阴性对照组的平均浓度为6.1$1.6 nM。早在5个月龄时，就检测到高于对照组上限的新喋呤浓度升高。新喋呤浓度超过20 NM的20例患者中有19例(95%)死亡或有严重的临床疾病。新喋呤浓度升高也与预后不良有关，即使第一个数值低于20 NM。
Neopterin concentrations in 50 children with human immunodeficiency virus infection were correlated with disease course. The neopterin concentrations ranged from 4 to 70 nM with a mean of 34.7$$25.1 (SD) nM compared with a mean of 6.1$$1.6 nM in the human immunodeficiency virus-negative control group. Elevated neopterin concentrations above the upper range of the control group were detected as early as 5 months of age. Nineteen of 20 patients (95%) with neopterin concentrations above 20 nM either died or have severe clinical disease. Increasing neopterin concentrations were also associated with poor prognosis even though the first value was below 20 nM.