Preoperative CYFRA 21-1 levels as a prognostic factor in c-stage I non-small cell lung cancer.
Preoperative CYFRA 21-1 levels as a prognostic factor in c-stage I non-small cell lung cancer.
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术前 CYFRA 21-1 水平作为 I 期非小细胞肺癌的预后因素。
DOI：
10.1016/j.ejcts.2007.06.032
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Y. Sakakibara
中科院分区：
文献类型：
--
作者：
Hisashi Suzuki;S. Ishikawa;H. Satoh;H. Ishikawa;Mitsuaki Sakai;Tatsuo Yamamoto;M. Onizuka;Y. Sakakibara
目的：术前测定CYFRA 21-1在早期非小细胞肺癌（NSCLC）中的临床意义尚不清楚。本研究的目的是澄清术前CYFRA 21-1水平在临床阶段（C-阶段）I NSCLC的预后价值。方法：101 C-阶段I NSCLC患者进行了完整的切除术的记录进行了分析，相关术前CYFRA 21-1水平切除标本和术后结果的病理因素。结果：6例（5.9%）CYFRA 21-1阳性（≥ 3.5ng/ml）。CYFRA 21-1正常组和高CYFRA 21-1组的5年生存率分别为83.3%和50.0%。高CYFRA 21-1的患者具有显著差的结果（P= 0.006）。在单因素分析中，术前血清CYFRA 21-1水平、pT、pN和p分期与预后显著相关。多因素分析结果显示，CYFRA 21-1水平仍是影响非小细胞肺癌预后的独立因素（相对危险度= 9.79，P = 0.002）。早期NSCLC患者术前CYFRA 21-1水平升高可能表明该亚组存在早期死亡的高风险，在额外的全身化疗下，该亚组有可能获得更好的生存率。
Objective:The clinical importance of preoperative CYFRA 21-1 measurement in early-stage non-small cell lung cancer (NSCLC) is still unclear. The aim of this study is to clarify the prognostic value of preoperative CYFRA 21-1 levels in clinical stage (c-stage) I NSCLC.Methods:The records of 101 c-stage I NSCLC patients who had undergone complete resection were analyzed to correlate preoperative CYFRA 21-1 levels to both the pathologic factors of resected specimens and postoperative outcomes. The cut-off value was set at 3.5 ng/ml.Results:Six cases (5.9%) showed high CYFRA 21-1 (≥3.5 ng/ml). The 5-year survival of normal and high CYFRA 21-1 groups was 83.3% and 50.0%, respectively. Patients with high CYFRA 21-1 had significantly poor outcomes (P= 0.006). In univariate analysis, preoperative serum CYFRA 21-1 level, pT, pN, and p-stage were significantly associated with prognosis. Multivariate analysis showed that only CYFRA 21-1 level was retained as an independent prognostic factor (relative risk = 9.79,P= 0.002).Conclusions:CYFRA 21-1 is an independent predictor of poor outcome for c-stage I NSCLC. Elevated preoperative CYFRA 21-1 levels in early-stage NSCLC may indicate a subgroup at high risk of early death, which has the potential for better survival with additional systemic chemotherapy.
DOI：
10.1016/s0022-5223(99)70294-1
发表时间：
1999-04-01
影响因子：
6
作者：
D'Amico, TA;Massey, M;Harpole, DH
通讯作者：
Harpole, DH