Photophysical properties of Zn(II) incorporated into liposomes
Photophysical properties of Zn(II) incorporated into liposomes
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DOI：
10.1142/s1088424602000166
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发表时间：
2002-01-01
影响因子：
1.5
通讯作者：
Dicelio, L
中科院分区：
文献类型：
--
作者：
Rodriguez, ME;Awruch, J;Dicelio, L
两亲性酞菁类化合物在光动力学治疗中被用作潜在的光敏剂。这些染料中的大多数的低水溶性是使用不同种类的媒介物作为内源性载体的原因。由于酞菁聚集体的非物理活性，重要的是提高它们的溶解度，以便在实体肿瘤模型中研究染料。另一方面，光动力治疗活性取决于酞菁在细胞中的位置和细胞组分的相互作用。在这项工作中，具有不同亲脂性的四取代锌（II）酞菁的物理化学性质被纳入脂质体的L-α-二肉豆蔻酰磷脂酰胆碱（DMPC）。报道了荧光量子产率、缔合常数及其在膜中的定位。版权所有（C）2002年卟啉和酞菁协会。
Amphiphilic phthalocyanines are used as potential photosensitizers in photodynamic therapy. The low water solubility of most of these dyes is the reason that different kinds of vehicles are employed as endogenous carriers. Due to the photophysical inactivity of the phthalocyanine aggregates, it is important to improve their solubility in order to study dyes in solid tumor models. On the other hand, the photodynamic therapy activity depends on the location of phthalocyanines in the cell and the interaction of cellular components. In this work, the photophysical properties of tetrasubstituted Zn(II) phthalocyanines with different lipophilic properties are incorporated into liposomes of L-alpha-dimyristoylphosphatidylcholine (DMPC). The fluorescence quantum yields, the association constants and their localization in the membranes are reported. Copyright (C) 2002 Society of Porphyrins & Phthalocyanines.