Quorum sensing inhibitory drugs as next generation antimicrobials: worth the effort?
Quorum sensing inhibitory drugs as next generation antimicrobials: worth the effort?
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DOI：
10.1007/s11908-008-0006-y
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发表时间：
2008-03-01
影响因子：
3.1
通讯作者：
Givskov, Michael
中科院分区：
文献类型：
--
作者：
Bjarnsholt, Thomas;Givskov, Michael
细菌耐药性对新型抗菌药物的开发提出了重大挑战。传统抗生素具有固有的过时性，因为它们会选择产生耐药性。细菌感染再次成为发达国家的严重威胁。特别是老年人、免疫力低下和住院患者，容易受到铜绿假单胞菌、金黄色葡萄球菌、表皮葡萄球菌等细菌感染。这些细菌形成基于生物膜的慢性感染，这是具有挑战性的，因为以生物膜形式存在的细菌细胞比浮游细菌细胞更能耐受抗生素。因此，研究应确定新的抗菌药物及其相应的靶点，以降低感染性细菌的生物膜形成能力或持久性。在这里，我们回顾了这样一个药物靶点：细菌细胞间通讯系统，或群体感应。
Bacterial resistance poses a major challenge to the development of new antimicrobial agents. Conventional antibiotics have an inherent obsolescence because they select for development of resistance. Bacterial infections have again become a serious threat in developed countries. Particularly, elderly, immunocompromised, and hospitalized patients are susceptible to infections caused by bacteria such as Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis. These bacteria form chronic, biofilm-based infections, which are challenging because bacterial cells living as biofilms are more tolerant to antibiotics than their planktonic counterparts. Therefore, research should identify new antimicrobial agents and their corresponding targets to decrease the biofilm-forming capability or persistence of the infectious bacteria. Here, we review one such drug target: bacterial cell-to-cell communication systems, or quorum sensing.