Role of the LDL Receptor-Related Protein 1 in Regulating Protease Activity and Signaling Pathways in the Vasculature.
Role of the LDL Receptor-Related Protein 1 in Regulating Protease Activity and Signaling Pathways in the Vasculature.
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DOI：
10.2174/1389450119666180511162048
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发表时间：
2018
影响因子：
3.2
通讯作者：
Strickland DK
中科院分区：
文献类型：
--
作者：
Au DT;Arai AL;Fondrie WE;Muratoglu SC;Strickland DK
主动脉瘤是一个重要的临床问题，因为它们在破裂发生之前很大程度上未被发现。目前，对导致动脉瘤形成的机制的理解是有限的。许多研究清楚地表明，血管平滑肌细胞在血管系统对血流动力学变化的发育和反应中起着重要作用，这些反应中的缺陷可能导致动脉瘤形成。LDL受体相关蛋白1（LRP 1）是平滑肌细胞的主要受体，其具有介导多种配体的内吞作用以及启动和调节信号通路的能力。人类和小鼠模型中的遗传证据揭示了LRP 1在维持血管系统完整性方面的关键作用。了解这一过程的机制是一个重要的研究领域，可能涉及LRP 1调节已知降解细胞外基质的蛋白酶水平的能力以及其调节信号传导事件的能力。
Aortic aneurysms represent a significant clinical problem as they largely go undetected until a rupture occurs. Currently, an understanding of mechanisms leading to aneurysm formation is limited. Numerous studies clearly indicate that vascular smooth muscle cells play a major role in the development and response of the vasculature to hemodynamic changes and defects in these responses can lead to aneurysm formation. The LDL receptor-related protein 1 (LRP1) is major smooth muscle cell receptor that has the capacity to mediate the endocytosis of numerous ligands and to initiate and regulate signaling pathways. Genetic evidence in humans and mouse models reveal a critical role for LRP1 in maintaining the integrity of the vasculature. Understanding the mechanisms by which this is accomplished represents an important area of research, and likely involves LRP1’s ability to regulate levels of proteases known to degrade the extracellular matrix as well as its ability to modulate signaling events.