AN EXPERIMENTAL-STUDY OF SPINAL-CORD EVOKED-POTENTIALS AND HISTOLOGIC-CHANGES FOLLOWING SPINAL-CORD HEATING
AN EXPERIMENTAL-STUDY OF SPINAL-CORD EVOKED-POTENTIALS AND HISTOLOGIC-CHANGES FOLLOWING SPINAL-CORD HEATING
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DOI：
10.1097/00007632-198911000-00014
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发表时间：
1989-11-01
期刊：
影响因子：
3
通讯作者：
HOMMA, T
中科院分区：
文献类型：
--
作者：
UCHIYAMA, S;YASHIRO, K;HOMMA, T
为了研究高温治疗癌症的安全性，用无线电波将狗的脊髓加热到43 ℃到47 ℃之间30分钟。硬膜外刺激后记录的脊髓诱发电位（SCEP）在44 ℃或以下时潜伏期缩短，波幅不变。在45 ℃或更高温度下，观察到振幅降低和潜伏期缩短，这是迄今为止尚未报道的现象。加热至45 ℃后，SCEP随温度降低而恢复，但组织学检查显示色素渗出、空泡化和出血。这些结果表明，脊髓可耐受温度不应超过44 ℃。
To study the safety of hyperthermia cancer treatment, canine spinal cords were heated with radio waves to between 43 C and 47 C for 30 minutes. Spinal cord evoked potentials (SCEP) studied by epidural recording after epidural stimulation showed shortened latency and unchanged amplitude at 44 C or below. At 45 C or above, reduction of amplitude combined with shortened latency was observed, a phenomenon that has not hitherto been reported. After heating to 45 C, SCEP recovered with the reduction of temperature, but histologic examinations showed pigment exudation, vacuolation, and hemorrhage. These results suggest that tolerable spinal cord temperature should not exceed about 44 C.