Information processing deficits in multiple sclerosis: A matter of complexity
Information processing deficits in multiple sclerosis: A matter of complexity
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DOI：
10.1017/s1355617707070580
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发表时间：
2007-05-01
影响因子：
2.6
通讯作者：
Shucard, David W.
中科院分区：
文献类型：
--
作者：
Parmenter, Brett A.;Shucard, Janet L.;Shucard, David W.
本研究探讨了复发缓解型多发性硬化症（RRMS）患者的加工速度（PS）和工作记忆（WM）之间的关系，通过n-back任务的表现来衡量。简单PS定义为0-back任务的反应时（RT），复杂PS定义为1-back和2-back任务的RT。参与者被管理所有三个n-back任务（0-，1-和2-back）。记录了总正确反应、总二联体和RT。正如预期的那样，所有参与者的RT随着WM负荷的增加而减慢。在所有任务中，MS患者的RT都比对照组慢，两组之间的RT差异在2-back任务中最大。当RT为简单的PS（0-回）解析从1-和2-回任务，MS患者仍然表现出受损的复杂PS相比，对照组。MS患者也作出了显着较少的总正确的反应，并有较少的二对比对照组只有2回任务。这些研究结果表明，WM和PS赤字都存在于RRMS中，并且随着WM需求的增加（从1到2回），PS和WM赤字变得更加突出。
This study examined the relationship between processing speed (PS) and working memory (WM), as measured by performance on an n-back task, in relapsing-remitting multiple sclerosis (RRMS) patients. Simple PS was defined as reaction time (RT) on the 0-back task and complex PS was defined as RT on both the 1-back and 2-back tasks. Participants were administered all three n-back tasks (0-, 1-, and 2-back). Total correct responses, total dyads, and RTs were recorded. As expected, RT for all participants slowed as WM load increased. MS patients had slower RTs than controls across all tasks, and the difference between groups for RT was greatest during the 2-back task. When RT for simple PS (0-back) was parsed from the 1- and 2-back tasks, MS patients still showed impaired complex PS compared to controls. MS patients also made significantly fewer total correct responses and had fewer dyads than controls only on the 2-back task. These findings suggest that both WM and PS deficits are present in RRMS, and that as WM demand increases (from 1- to 2-back) both PS and WM deficits become more prominent.