A Novel Microflow Phantom Dedicated to Ultrasound Microvascular Measurements
A Novel Microflow Phantom Dedicated to Ultrasound Microvascular Measurements
复制标题
一种专用于超声微血管测量的新型微流模型
DOI：
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发表时间：
2018
期刊：
影响因子：
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通讯作者：
S. Pitre
中科院分区：
文献类型：
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作者：
Virginie Grand;Jean;I. Leguerney;B. Benatsou;J. Grégoire;Georges Willoquet;A. Bouakaz;N. Lassau;S. Pitre
肿瘤微血管化是抗血管生成治疗反应的生物标志物，可通过超声成像准确评估。用于可视化慢血流的成像模式包括能量多普勒成像、动态对比增强超声检查以及最近的微血管多普勒。流动体模用于评估多普勒成像技术的性能，但它们不具有稳定的流动和足够小的通道。我们报告了一种用于稳健且稳定的微流量测量和微血管化研究的新型装置。该原型基于微流体技术，具有直径范围从 147 微米到最大 436 µm 的无壁圆柱形通道，采用软硅聚合物铸造，并通过微流体流量压力控制器进行灌注。该装置使用 49 至 146 µL/min 的流速进行评估，三分钟内的变异系数小于 1%，对应于 6 至 142 mm/s 的速度。这使我们能够在存在模拟生理运动的振动的情况下，在这些流速下评估并确认超级微血管成像多普勒模式与功率多普勒模式相比的可靠性。
Tumor microvascularization is a biomarker of response to antiangiogenic treatments and is accurately assessed by ultrasound imaging. Imaging modes used to visualize slow flows include Power Doppler imaging, dynamic contrast-enhanced ultrasonography, and more recently, microvascular Doppler. Flow phantoms are used to evaluate the performance of Doppler imaging techniques, but they do not have a steady flow and sufficiently small channels. We report a novel device for robust and stable microflow measurements and the study of the microvascularization. Based on microfluidics technology, the prototype features wall-less cylindrical channels of diameters ranging from as small as 147 up to 436 µm, cast in a soft silicone polymer and perfused via a microfluidic flow pressure controller. The device was assessed using flow rates from 49 to 146 µL/min, with less than 1% coefficient of variation over three minutes, corresponding to velocities of 6 to 142 mm/s. This enabled us to evaluate and confirm the reliability of the Superb Microvascular Imaging Doppler mode compared with the Power Doppler mode at these flow rates in the presence of vibrations mimicking physiological motion.
影响因子：
2.9
作者：
Nayak, Rohit;Kumar, Viksit;Alizad, Azra
通讯作者：
Alizad, Azra