Role of the Wilms' tumour transcription factor, Wt1, in blood vessel formation
Role of the Wilms' tumour transcription factor, Wt1, in blood vessel formation
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DOI：
10.1007/s00424-008-0621-3
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发表时间：
2009-06-01
影响因子：
4.5
通讯作者：
Wagner, Nicole
中科院分区：
文献类型：
--
作者：
Scholz, Holger;Wagner, Kay-Dietrich;Wagner, Nicole
血管形成对于正常器官发育和肿瘤生长很重要。心脏中存在高度专业化的血管形成发育程序，对于正常的心脏发生至关重要。从小鼠模型中可以清楚地看出，维尔姆斯肿瘤蛋白 Wt1 是正常心脏发育所必需的。 Wt1 最初因其在肾母细胞瘤或肾母细胞瘤中的突变失活而被确定为肿瘤抑制基因，如今被认为在器官发生和病理生理学中具有更广泛的功能。 Wt1的多重任务不仅限于肾脏，还涉及心脏和血管系统。在这篇综述中，我们重点关注有关 Wt1 在心脏和冠状血管发育中的重要性以及已确定的分子机制的最新发现。此外，我们还讨论了 Wt1 在心肌缺血血管反应中的意义及其作为肿瘤血管生成促进剂的致癌潜力。
Blood vessel formation is important for normal organ development and tumour growth. A highly specialised developmental program of vessel formation exists in the heart and is essential for normal cardiogenesis. From mouse models, it became clear that the Wilms' tumour protein Wt1 is required for normal heart development. Originally identified as a tumour suppressor gene based on its mutational inactivation in Wilms' tumour or nephroblastoma, Wt1 is nowadays recognised to have much broader functions in organogenesis and pathophysiology. The multiple tasks of Wt1 are not only limited to the kidney but involve the heart and vascular system as well. In this review, we focus on recent findings about the importance of Wt1 in heart and coronary vessel development and the identified molecular mechanisms. In addition, we discuss the implication of Wt1 in the vascular response to myocardial ischaemia and its oncogenic potential as a promoter of tumour angiogenesis.