Circulating lymphangiogenic factors in preeclampsia.
Circulating lymphangiogenic factors in preeclampsia.
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DOI：
10.3109/10641955.2012.697953
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发表时间：
2013
影响因子：
1.5
通讯作者：
Rana S
中科院分区：
文献类型：
--
作者：
Lely AT;Salahuddin S;Holwerda KM;Karumanchi SA;Rana S
先兆子痫是一种人类妊娠特异性疾病，其特征在于由于高水平的循环可溶性血管内皮生长因子1（sVEGFR-1）而导致的抗血管生成状态。然而，淋巴管生成在先兆子痫中的作用尚未研究。最近，受损的VEGF-C（调节淋巴管生成的因子）信号转导已被牵连在间质性水肿和盐敏感性高血压的发病机制。因此，我们假设循环VEGF-C及其循环受体（sVEGFR-2和sVEGFR-3）也可能在先兆子痫中发生改变，并与表型的严重程度相关。我们分析了妊娠期高血压（GHTN，n=20）、先兆子痫（PE，n = 20）和正常妊娠（NP，n = 20）妇女在妊娠晚期的VEGF-C、sVEGFR-1、sVEGFR-2和sVEGFR-3的血浆水平，并以pg/ml为单位报告平均值± SD。如前所述，PE受试者的sVEGFR-1水平（19938 ± 12973）显著高于GHTN（7156 ± 5432），p<0.01或NP（7760 ± 6018），p<0.01。GHTN受试者的VEGF-C水平（676 ± 323）低于PE（1335 ± 625），p<0.01，但与NP（971 ± 556）无统计学差异，p=0.11。与GHTN或NP相比，PE中存在sVEGFR-2降低的趋势。有趣的是，与NP（83709 ± 24983）相比，PE（54371 ± 21107）中的sVEGFR-3显著较低，p<0.01，但与GHTN（54642 ± 26947）相比无差异。与GHTN（113 ± 72）（p<0.01）或NP（133 ± 91）（p<0.01）相比，PE期间sVEGFR-2+sVEGFR-3/VEGF-C的比率显著降低（57 ± 38）。先兆子痫的特征在于循环促淋巴管生成状态，如sVEGFR-3降低、sVEGFR-2轻微降低、VEGF-C增加和sVEGFR-2+sVEGFR-3/VEGF-C的比率显著降低所证明的。我们的数据表明，先兆子痫的循环前淋巴管生成状态可能是对水肿和高血压的代偿反应。需要进一步的研究来评估先兆子痫期间淋巴管生成信号通路改变的临床相关性。
Preeclampsia, a human pregnancy specific disorder is characterized by an anti-angiogenic state due to high levels of circulating soluble vascular endothelial growth factor 1 (sVEGFR-1). However, the role of lymphangiogenesis in preeclampsia has not been investigated. Recently, impaired VEGF-C (factor that regulates lymphangiogenesis) signalling has been implicated in the pathogenesis of interstitial edema and salt-sensitive hypertension. Therefore, we hypothesized that circulating VEGF-C and its circulating receptors (sVEGFR-2 and sVEGFR-3) may also be altered in preeclampsia and correlate with the severity of the phenotype. We analyzed plasma levels of VEGF-C, sVEGFR-1, sVEGFR-2 and sVEGFR-3 in women with gestational hypertension (GHTN, n=20), preeclampsia (PE, n=20) and normotensive pregnancies (NP, n=20) in the third trimester and values reported as mean ± SD in pg/ml. As previously reported, sVEGFR-1 levels were significantly higher in subjects with PE (19938 ± 12973) than in GHTN (7156 ± 5432), p<0.01 or NP (7760 ± 6018), p<0.01. VEGF-C levels were lower in subjects with GHTN (676 ± 323) than in PE (1335 ± 625), p<0.01, but not statistically different than in NP (971 ± 556), p=0.11. There was a trend towards lower sVEGFR-2 in PE as compared to GHTN or NP. Interestingly sVEGFR-3 was significantly lower in PE (54371 ± 21107) as compared to NP (83709 ± 24983), p<0.01, but not different as compared to GHTN (54642 ± 26947). The ratio of sVEGFR-2+sVEGFR-3/VEGF-C was dramatically lower during PE (57 ± 38) as compared to GHTN (113 ± 72), p<0.01 or NP (133 ± 91), p<0.01. Preeclampsia is characterized by circulating pro-lymphangiogenic state as evidenced by decreased sVEGFR-3, slightly decreased sVEGFR-2, increased VEGF-C and a dramatically lower ratio of sVEGFR-2+sVEGFR-3/VEGF-C. Our data suggests that the circulating pro-lymphoangiogenic state during preeclampsia may be a compensatory response to edema and hypertension. Additional studies are needed to evaluate the clinical relevance of the altered lymphangiogenic signalling pathway during preeclampsia.
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影响因子：
82.9
作者：
Venkatesha, Shivalingappa;Toporsian, Mourad;Karumanchi, S. Ananth
通讯作者：
Karumanchi, S. Ananth
影响因子：
20.1
作者：
Ahmad, S;Ahmed, A
通讯作者：
Ahmed, A
影响因子：
15.9
作者：
Maynard, SE;Min, JY;Karumanchi, SA
通讯作者：
Karumanchi, SA
DOI：
10.1161/hypertensionaha.111.182170
发表时间：
2012-02
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Rajakumar A;Cerdeira AS;Rana S;Zsengeller Z;Edmunds L;Jeyabalan A;Hubel CA;Stillman IE;Parikh SM;Karumanchi SA
通讯作者：
Karumanchi SA
影响因子：
82.9
作者：
Machnik, Agnes;Neuhofer, Wolfgang;Titze, Jens
通讯作者：
Titze, Jens