HEMODYNAMICS AT REST AND DURING EXERCISE IN NORMAL PREGNANCY AS STUDIED BY CARDIAC CATHETERIZATION
HEMODYNAMICS AT REST AND DURING EXERCISE IN NORMAL PREGNANCY AS STUDIED BY CARDIAC CATHETERIZATION
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DOI：
10.1172/jci103205
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发表时间：
1955-01-01
影响因子：
15.9
通讯作者：
BRAUNWALD, E
中科院分区：
文献类型：
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作者：
BADER, RA;BADER, ME;BRAUNWALD, E
对44例正常妊娠妇女在不同妊娠阶段进行心导管检查，结果显示，与非妊娠对照组相比，心输出量最大增加42%。峰值出现在第25- 27周，并在足月前降至正常。每搏输出量的变化小于心输出量的变化，而动静脉氧差变化小于心输出量的变化（最低平均值为3.4体积%）。全身动脉压没有显著变化，因此计算的总外周阻力在最大心输出量期间降低，并在分娩前恢复正常。心输出量对运动的反应在妊娠的各个阶段都是正常的。右心和肺动脉的压力仅轻微升高，没有明显高于正常值。孕25- 35周，27例患者中6例静息时右室舒张末压升高。
Cardiac catheterization in 44 normal pregnant women at various stages of pregnancy revealed a maximum increase of 42% in cardiac output compared with nonpregnant controls. Peak values were found at the 25-27th weeks with a fall to normal prior to term. Changes in stroke volume paralleled those in cardiac output while arteriovenous O2 difference varied reciprocally (lowest mean value 3.4 volumes %). Systemic arterial pressures were not significantly changed hence calculated total peripheral resistance was decreased at the period of maximum cardiac output with return to normal prior to parturition. Cardiac output response to exercise was normal at all stages of gestation. Pressures in the right heart and pulmonary artery were only slightly increased without significant elevation above normal. Right ventricular end diastolic pressure was elevated in 6 of 27 patients at rest in the 25-35th weeks of gestation.