Insulin-like growth factor I and impaired glucose tolerance
Insulin-like growth factor I and impaired glucose tolerance
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DOI：
10.1159/000080767
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发表时间：
2004-01-01
期刊：
影响因子：
--
通讯作者：
Ong, K
中科院分区：
文献类型：
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作者：
Dunger, D;Yuen, K;Ong, K
循环胰岛素样生长因子I （IGF-I）对葡萄糖代谢的影响已得到广泛认识。igf - 1在维持β细胞质量和调节内源性生长激素（GH）水平方面也很重要。较低的igf - 1水平可以解释出生体积小与矮个子肥胖成年人患2型糖尿病风险之间的联系。在最近的一项前瞻性研究中，儿童胰岛素分泌与IGF-I水平和身高生长有关，而胰岛素敏感性与出生后早期体重增加有关。IGF1基因的常见遗传多态性与出生时体型小、出生后生长和未来患糖尿病的风险有关，但这些结果并不一致。最近的成人研究表明，较低的igf - 1基线水平预示着随后的糖耐量受损（IGT）、2型糖尿病和心血管疾病的发展。低剂量的生长激素治疗，在最大限度地减少生长激素的溶脂作用，并有能力增加igf - 1水平，提高年轻健康成人和GH缺乏成人的胰岛素敏感性，并增加IGT个体的胰岛素分泌。低剂量GH、重组IGF-I或IGF-I/ igf结合蛋白3联合治疗是否能预防高危正常血糖和GH缺乏个体未来发生IGT或2型糖尿病，值得进一步的长期研究。版权所有(C) 2004 S. Karger AG，巴塞尔。
The effects of circulating insulin-like growth factor I (IGF-I) on glucose metabolism are well recognized. IGF-I is also important in maintaining beta-cell mass and regulating endogenous growth hormone (GH) levels. Low IGF-I levels could explain links between small birth size and the risk of developing type 2 diabetes mellitus in short, obese adults. In a recent prospective study, childhood insulin secretion was related to IGF-I levels and statural growth, whereas insulin sensitivity was related to early post-natal weight gain. Common genetic polymorphisms in the IGF1 gene have been linked to small birth size, post-natal growth and future diabetes risk, but these results have been inconsistent. Recent adult studies have demonstrated that lower baseline IGF-I levels predict the subsequent development of impaired glucose tolerance (IGT), type 2 diabetes and cardiovascular disease. Administration of low-dose GH therapy, at a dose that minimizes the lipolytic effects of GH and has the ability to increase IGF-I levels, enhances insulin sensitivity in young healthy adults and in GH-deficient adults and increases insulin secretion in individuals with IGT. Whether the administration of low-dose GH, recombinant IGF-I or combined IGF-I/IGF-binding protein 3 therapy prevents future development of IGT or type 2 diabetes in high-risk normoglycaemic and GH-deficient individuals merits further long-term studies. Copyright (C) 2004 S. Karger AG, Basel.