Gliomatosis cerebri may present as an atypical Parkinsonian syndrome
Gliomatosis cerebri may present as an atypical Parkinsonian syndrome
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DOI：
10.1002/mds.10665
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发表时间：
2004-03-01
影响因子：
8.6
通讯作者：
Molho, ES
中科院分区：
文献类型：
--
作者：
Molho, ES
一位85岁男性，患有进行性运动不能强直综合征3年，伴共济失调、福尔斯、左旋多巴无反应性和自主神经功能障碍。在疾病的早期，头颅磁共振成像（MRI）被认为显示脑桥扩大，但后来被专家重新解释为正常。随后的两次头颅MRI被认为仅显示轻度萎缩。初步临床诊断为多系统萎缩。患者在出现症状后4年死亡。病理学检查显示多个脑区弥漫性浸润，星形细胞和小胶质细胞来源的细胞与脑胶质瘤病的诊断一致。(C)2004年，《运动障碍协会》。
An 85-year-old man presented with 3 years of a progressive akinetic rigid syndrome with ataxia, falls, levodopa unresponsiveness, and autonomic dysfunction. Early in the course of illness, cranial magnetic resonance imaging (MRI) was thought to show pontine enlargement but later was reinterpreted by experts as normal. Two subsequent cranial MRIs were believed to show only mild atrophy. An initial clinical diagnosis of multiple system atrophy was made. The patient died 4 years after the onset of symptoms. Pathological examination revealed diffuse infiltration of multiple brain regions with cells of astrocytic and microglial origin consistent with a diagnosis of gliomatosis cerebri. (C) 2004 Movement Disorder Society.