Large-scale parent-child comparison confirms a strong paternal influence on telomere length
Large-scale parent-child comparison confirms a strong paternal influence on telomere length
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DOI：
10.1038/ejhg.2009.178
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发表时间：
2010-03-01
影响因子：
5.2
通讯作者：
Roos, Goran
中科院分区：
文献类型：
--
作者：
Nordfjall, Katarina;Svenson, Ulrika;Roos, Goran
端粒长度被证明具有遗传成分，并且已经提出了父系遗传和X连锁遗传。我们调查了962名年龄在0到102岁之间的人的血细胞端粒长度。分析了不同年龄组父母-子女之间以及祖孙之间端粒长度的相关性。父亲端粒长度与子女端粒长度呈高度显著相关（r=0.454，P
Telomere length is documented to have a hereditary component, and both paternal and X-linked inheritance have been proposed. We investigated blood cell telomere length in 962 individuals with an age range between 0 and 102 years. Telomere length correlations were analyzed between parent-child pairs in different age groups and between grandparent-grandchild pairs. A highly significant correlation between the father's and the child's telomere length was observed (r=0.454, P