Simulation of the BNCT of Brain Tumors Using MCNP Code: Beam Designing and Dose Evaluation
Simulation of the BNCT of Brain Tumors Using MCNP Code: Beam Designing and Dose Evaluation
复制标题
使用 MCNP 代码模拟脑肿瘤 BNCT：射束设计和剂量评估
DOI：
10.22038/ijmp.2012.150
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发表时间：
2012
影响因子：
--
通讯作者：
S. Masoudi
中科院分区：
文献类型：
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作者：
F. Rasouli;S. Masoudi
前言BNCT是一种有效的方法，以破坏脑肿瘤细胞，而保留健康组织。超热中子的推荐通量为109 n/cm 2 s，这对深部肿瘤最有效。本文指出，采用D-T中子源和优化束流整形装置（BSA），可以在合理的时间内治疗脑肿瘤，并满足IAEA推荐的所有标准。材料与方法基于D-T中子发生器的BSA由中子倍增器系统、减速器、反射器和准直器组成。模拟的Snyder头部体模用于评估由于设计的射束照射而引起的组织中的剂量分布。使用蒙特卡罗程序MCNP-4C进行这些计算。 结果优化后的BSA中子束流在束流口处具有足够的超热通量，中子和γ污染物被尽可能地去除。此外，它表明，增加J/Φ，作为一个衡量光束方向性，导致改善光束性能和肿瘤周围的健康组织的生存。结论根据模拟结果，基于D-T中子源的系统满足空气中的各项参数要求，适合于医院内安装。此外，深度-剂量曲线研究设计的束在组织中的适当性能。结果与其他设施的性能相媲美。
Introduction BNCT is an effective method to destroy brain tumoral cells while sparing the healthy tissues. The recommended flux for epithermal neutrons is 109 n/cm2s, which has the most effectiveness on deep-seated tumors. In this paper, it is indicated that using D-T neutron source and optimizing of Beam Shaping Assembly (BSA) leads to treating brain tumors in a reasonable time where all IAEA recommended criteria are met. Materials and Methods The proposed BSA based on a D-T neutron generator consists of a neutron multiplier system, moderators, reflector, and collimator. The simulated Snyder head phantom is used to evaluate dose profiles in tissues due to the irradiation of designed beam. Monte Carlo Code, MCNP-4C, was used in order to perform these calculations. Results The neutron beam associated with the designed and optimized BSA has an adequate epithermal flux at the beam port and neutron and gamma contaminations are removed as much as possible. Moreover, it was showed that increasing J/Φ, as a measure of beam directionality, leads to improvement of beam performance and survival of healthy tissues surrounding the tumor. Conclusion According to the simulation results, the proposed system based on D-T neutron source, which is suitable for in-hospital installations, satisfies all in-air parameters. Moreover, depth-dose curves investigate proper performance of designed beam in tissues. The results are comparable with the performances of other facilities.