Neural Correlates of Trait Rumination During an Emotion Interference Task in Women With PTSD.
Neural Correlates of Trait Rumination During an Emotion Interference Task in Women With PTSD.
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在PTSD女性的情绪干扰任务中，性状反思的神经相关性。
DOI：
10.1002/jts.22112
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发表时间：
2016-08
影响因子：
3.3
通讯作者：
Sheline YI
中科院分区：
文献类型：
--
作者：
Buchholz KR;Bruce SE;Koucky EM;Artime TM;Wojtalik JA;Brown WJ;Sheline YI
反刍，被定义为重复的，消极的，自我为中心的思维，被假设为一个transdiagnosis因素，与抑郁，焦虑和创伤后应激障碍（PTSD）。理论表明，在PTSD患者中，反刍作为一种认知回避因素，通过抑制创伤事件的认知和情感处理，随后干扰治疗参与和结果，从而有助于维持症状。关于PTSD女性患者反刍的神经相关性知之甚少。目前的研究利用功能磁共振成像（fMRI）检查神经相关，在情绪干扰任务，自我报告反刍的PTSD妇女。通过一所大学的创伤诊所招募了患有PTSD的女性（39），并完成了临床评估，其中包括PTSD症状，反刍和抑郁症状的测量，以及神经成像会议，其中参与者被管理情绪干扰任务。在任务期间，自我报告的反刍和右眶额叶皮层的活动之间存在显著关系，BA 11; t（37）= 5.62，p = 0.004，k = 46。这一发现表明，与反刍水平较低的女性相比，具有较高反刍水平的PTSD女性可能更难抑制负面情绪刺激。
Rumination, defined as repetitive, negative, self-focused thinking, is hypothesized to be a transdiagnostic factor that is associated with depression, anxiety, and posttraumatic stress disorder (PTSD). Theory has suggested that in individuals with PTSD, rumination serves as a cognitive avoidance factor that contributes to the maintenance of symptoms by inhibiting the cognitive and emotional processing of the traumatic event, subsequently interfering with treatment engagement and outcome. Little is known about the neural correlates of rumination in women with PTSD. The current study utilized functional magnetic resonance imaging (fMRI) to examine neural correlates, during an emotion interference task, of self-reported rumination in women with PTSD. Women with PTSD (39) were recruited through a university-based trauma clinic and completed a clinical evaluation that included measures of PTSD symptoms, rumination, and depressive symptoms, as well as a neuroimaging session in which the participants were administered an emotion interference task. There was a significant relationship between self-reported rumination and activity in the right orbital frontal cortex, BA 11; t(37) = 5.62, p = .004, k = 46 during the task. This finding suggests that women with PTSD who have higher levels of rumination, may experience greater difficulty inhibiting negative emotional stimuli as compared to women with lower levels of rumination.