Gene editing therapeutics based on mRNA delivery.
Gene editing therapeutics based on mRNA delivery.
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DOI：
10.1016/j.addr.2023.115026
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发表时间：
2023-07
影响因子：
16.1
通讯作者：
J. Popovitz;Rohit Sharma;R. Hoshyar;Beob Soo Kim;N. Murthy;Kunwoo Lee
中科院分区：
文献类型：
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作者：
J. Popovitz;Rohit Sharma;R. Hoshyar;Beob Soo Kim;N. Murthy;Kunwoo Lee
The field of gene editing has received much attention in recent years due to its immense therapeutic potential. In particular, gene editing therapeutics, such as the CRISPR-Cas systems, base editors, and other emerging gene editors,offer the opportunity to address previously untreatable disorders. This review aims to summarize the therapeutic applications of gene editing based on mRNA delivery. We introduce gene editing therapeutics using mRNA and focus on engineering and improvement of gene editing technology. We subsequently examineex vivoandin vivogene editing techniques and conclude with an exploration of the next generation of CRISPR and base editing systems.
