Ion parking during ion/ion reactions in electrodynamic ion traps
Ion parking during ion/ion reactions in electrodynamic ion traps
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DOI：
10.1021/ac0109671
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发表时间：
2002-01-15
影响因子：
7.4
通讯作者：
Wells, JM
中科院分区：
文献类型：
--
作者：
McLuckey, SA;Reid, GE;Wells, JM
在适当的离子密度条件下，可以通过对离子阱的一个或多个电极施加振荡电压来选择性地抑制四极离子阱中离子/离子反应的速率。用偶极共振激发作用于三维四极离子阱的端盖电极，证明了这一现象。应用谐振激励电压来抑制特定范围内离子质量电荷比的离子/离子反应速率被称为“离子停车”。速率抑制的基础是(i)离子/离子反应对的相对速度增加，这减少了离子/离子捕获的横截面，至少在某些情况下，（ii）减少了带正电荷和带负电荷的离子云的物理重叠时间。离子停放实验的效率和特异性高度依赖于离子密度、俘获条件、离子电荷状态和共振激发条件。本文说明了离子停放实验以及应用于原存在于一系列电荷状态到选定电荷状态的离子浓度以及从源自简单蛋白质混合物的一组离子中选择特定离子。
Under appropriate ion density conditions, it is possible to selectively inhibit rates of ion/ion reactions in a quadrupole ion trap via the application of oscillatory voltages to one or more electrodes of the ion trap. The phenomenon is demonstrated using dipolar resonance excitation applied to the end-cap electrodes of a three-dimensional quadrupole ion trap. The application of a resonance excitation voltage tuned to inhibit the ion/ion reaction rate of a specific range of ion mass-to-charge ratios is referred to as "ion parking". The bases for rate inhibition are (i) an increase in the relative velocity of the ion/ion reaction pair, which reduces the cross section for ion/ion capture and, at least in some cases, (ii) reduction in the time of physical overlap of positively charged and negatively charged ion clouds. The efficiency and specificity of the ion parking experiment is highly dependent upon ion densities, trapping conditions, ion charge states, and resonance excitation conditions. The ion parking experiment is illustrated herein along with applications to the concentration of ions originally present over a range of charge states into a selected charge state and in the selection of a particular ion from a set of ions derived from a simple protein mixture.