Protective effects of the whisky congeners on ethanol-induced gastric mucosal damage
Protective effects of the whisky congeners on ethanol-induced gastric mucosal damage
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DOI：
10.1111/j.1530-0277.2006.00319.x
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发表时间：
2007-03-01
影响因子：
3.2
通讯作者：
Ishihara, Kazuhiko
中科院分区：
文献类型：
--
作者：
Goso, Yukinobu;Ueno, Masaki;Ishihara, Kazuhiko
背景：酒精和威士忌的摄入都可诱发急性消化道出血。方法：采用大鼠乙醇性胃粘膜损伤模型，观察威士忌酒中除乙醇外的其他物质对乙醇性胃粘膜损伤的影响。以5 mg/kg体重的剂量（相当于威士忌中所含同系物的浓度）同时给予威士忌同系物和50%乙醇，没有抑制出血性病变，但在150 mg/kg的剂量下抑制它们。在摄入乙醇前30分钟用威士忌同系物处理以0.5至150 mg/kg的剂量依赖性方式防止乙醇诱导的胃损伤。同源物的丁醇提取物与乙酸乙酯提取物或水馏分相比，显示出最强的预防作用。吲哚美辛的同类物治疗前60分钟的管理，部分抑制了同类物的保护作用，表明在这种机制中的部分贡献的野牡丹素。同源物没有防止粘膜作为一个“轻度刺激”的行动，因为使用抗粘蛋白单克隆抗体的免疫组化研究表明，没有损害诱导的管理的同源物。结论：目前的结果表明，威士忌同源物对乙醇诱导的胃粘膜损伤有保护活性。
Background: The ingestion of both ethanol and whisky can induce acute gastrointestinal bleeding. The effects of the congeners, substances other than ethanol in whisky, on the ethanol-induced gastric mucosal damage were examined in the rat model.Methods: After the whisky congeners were intragastrically administered previous to or simultaneous with ethanol ingestion, the gastric damage was macroscopically and microscopically measured.Results: The simultaneous administration of the whisky congeners at a dose of 5 mg/kg body weight, which corresponds to the concentration of congeners contained in whisky, with 50% ethanol did not inhibit the hemorrhagic lesions, but inhibited them at a dose of 150 mg/kg. The treatment with the whisky congeners 30 minutes before the ethanol ingestion prevented the ethanol-induced gastric damage in a dose-dependent manner at 0.5 to 150 mg/kg. The butanol extract of the congeners revealed the strongest prevention compared with the ethyl acetate extract or the water fraction. The administration of indomethacin 60 minutes before the congener treatment partly inhibited the protective effects of the congeners, indicating the partial contribution of prostaglandins in this mechanism. The congeners did not prevent the mucosa by action as a "mild irritant" because the immunohistochemical studies using the antimucin monoclonal antibodies showed that no damage was induced by the administration of the congeners.Conclusions: The present results showed that the whisky congeners have a protective activity against ethanol-induced gastric mucosal injury.