Activity of medullary respiratory neurons during ventilator-induced apnea in sleep and wakefulness.
Activity of medullary respiratory neurons during ventilator-induced apnea in sleep and wakefulness.
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睡眠和清醒时呼吸机引起的呼吸暂停期间髓质呼吸神经元的活动。
DOI：
10.1152/jappl.1998.84.3.922
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Vidruk,EH
中科院分区：
文献类型：
--
作者：
Orem,J;Vidruk,EH
猫在睡眠和清醒时进行机械通气会导致呼吸暂停，通常在呼吸机的两到三个周期内发生。我们记录了四只成年猫在正常呼吸和机械通气引起的呼吸暂停期间的 137 个髓质呼吸神经元。我们假设呼吸暂停期间呼吸神经元的残余活动可能揭示其原因。结果表明，残余活性取决于：1）细胞的非呼吸输入量（非呼吸输入越多，残余活性越多）；2）细胞类型（呼气细胞比吸气细胞具有更多残余活性）；3）细胞类型（呼气细胞比吸气细胞具有更多残余活性）。 3) 意识状态（清醒和快速眼动睡眠中的残余活动比非快速眼动睡眠中的残余活动更多）。没有一个细胞在通气过程中表现出可以解释呼吸暂停的激活。大约一半细胞的残余活性与呼吸机同相调节。通过使用效应大小统计来量化这种调制的强度，结果发现这种调制的强度很弱。调节模式并不支持机械感受器刺激某些呼吸细胞，进而抑制其他细胞的观点。事实上，大多数吸气和呼气细胞在通气的通气紧缩-充气过渡期间放电。残余活动未能揭示呼吸暂停的原因，但表明在呼吸暂停期间，呼吸神经元的行为就好像它们被解除抑制和障碍一样。
Mechanical ventilation of cats in sleep and wakefulness causes apnea, often within two to three cycles of the ventilator. We recorded 137 medullary respiratory neurons in four adult cats during eupnea and during apnea caused by mechanical ventilation. We hypothesized that the residual activity of respiratory neurons during apnea might reveal its cause(s). The results showed that residual activity depended on1) the amount of nonrespiratory inputs to the cell (cells with more nonrespiratory inputs had greater amounts of residual activity);2) the cell type (expiratory cells had more residual activity than inspiratory cells); and3) the state of consciousness (more residual activity in wakefulness and rapid-eye-movement sleep than in non-rapid-eye-movement sleep). None of the cells showed an activation during ventilation that could explain the apnea. Residual activity of approximately one-half of the cells was modulated in phase with the ventilator. The strength of this modulation was quantified by using an effect-size statistic and was found to be weak. The patterns of modulation did not support the idea that mechanoreceptors excite some respiratory cells that, in turn, inhibit others. Indeed, most cells, inspiratory and expiratory, discharged during the deflation-inflation transition of ventilation. Residual activity failed to reveal the cause of apnea but showed that during apnea respiratory neurons act as if they were disinhibited and disfacilitated.