Initiation and completion rates for latent tuberculosis infection treatment: a systematic review.
Initiation and completion rates for latent tuberculosis infection treatment: a systematic review.
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DOI：
10.1186/s12879-016-1550-y
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发表时间：
2016-05-17
影响因子：
3.7
通讯作者：
van der Werf MJ
中科院分区：
文献类型：
--
作者：
Sandgren A;Vonk Noordegraaf-Schouten M;van Kessel F;Stuurman A;Oordt-Speets A;van der Werf MJ
控制潜伏性结核病感染（LTBI）是消除结核病的重要步骤。在大多数诊断为LTBI的病例中，预防性治疗将防止疾病的发展。然而，低启动率和完成率影响了预防性治疗的有效性。本研究的目的是系统地回顾关于LTBI治疗方案在一般人群和特定LTBI人群中的启动率和完成率的数据。对截至2014年2月发表的文献（PubMed，Embase）进行了系统综述。共发现45项关于LTBI治疗启动率的研究和83项关于LTBI治疗完成率的研究，这些研究提供了一般人群中LTBI患者的启动率（IR）和完成率（CR（IR 26- 99%，CR 39- 96%），病例接触（IR 40- 95%，CR 48- 82%），医护人员（IR 47- 98%，CR 17- 79%），无家可归者（IR 34- 90%，CR 23- 71%），注射毒品者（IR 52- 91%，CR 38- 89%），艾滋病毒感染者（IR 67- 92%，CR 55- 95%），囚犯（IR 7- 90%，CR 4- 100%），移民（IR 23- 97%，CR 7- 86%）和合并症患者（IR 82- 93%，CR 75- 92%）。一般来说，短期LTBI治疗方案的完成率高于长期LTBI治疗方案。LTBI治疗方案的启动率和完成率经常是次优的，并且在不同人群中差异很大。本文的在线版本（doi：10.1186/s12879-016-1550-y）包含补充材料，可供授权用户使用。
Control of latent tuberculosis infection (LTBI) is an important step towards tuberculosis elimination. Preventive treatment will prevent the development of disease in most cases diagnosed with LTBI. However, low initiation and completion rates affect the effectiveness of preventive treatment. The objective was to systematically review data on initiation rates and completion rates for LTBI treatment regimens in the general population and specific populations with LTBI. A systematic review of the literature (PubMed, Embase) published up to February 2014 was performed. Forty-five studies on initiation rates and 83 studies on completion rates of LTBI treatment were found. These studies provided initiation rates (IR) and completion rates (CR) in people with LTBI among the general population (IR 26–99 %, CR 39–96 %), case contacts (IR 40–95 %, CR 48–82 %), healthcare workers (IR 47–98 %, CR 17–79 %), the homeless (IR 34–90 %, CR 23–71 %), people who inject drugs (IR 52–91 %, CR 38–89 %), HIV-infected individuals (IR 67–92 %, CR 55–95 %), inmates (IR 7–90 %, CR 4–100 %), immigrants (IR 23–97 %, CR 7–86 %), and patients with comorbidities (IR 82–93 %, CR 75–92 %). Generally, completion rates were higher for short than for long LTBI treatment regimens. Initiation and completion rates for LTBI treatment regimens were frequently suboptimal and varied greatly within and across different populations. The online version of this article (doi:10.1186/s12879-016-1550-y) contains supplementary material, which is available to authorized users.