EFFECT OF SELECTION ON GENETIC-VARIABILITY - SIMULATION STUDY
EFFECT OF SELECTION ON GENETIC-VARIABILITY - SIMULATION STUDY
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DOI：
10.1017/s0016672300016797
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发表时间：
1976-01-01
影响因子：
1.5
通讯作者：
BULMER, MG
中科院分区：
文献类型：
--
作者：
BULMER, MG
计算机模拟研究了稳定和破坏性选择对多基因性状的影响。遗传变异的三个组成部分分别代表基因频率的变化、哈迪-温伯格平衡的偏离和连锁不平衡。在随机配合下，第一和第三部分是最重要的。根据先前关于选择下平衡稳定性的理论工作来解释观察到的基因频率的变化。基因型变异的巨大而快速的变化是由于选择下连锁不平衡的产生造成的；观察到的变化与理论预测的变化非常吻合。
Computer simulations studied the effects of stabilizing and disruptive selection on a polygenic character. Three components of genetic variability represent changes in gene frequencies, departures from Hardy-Weinberg equilibrium and linkage disequilibrium, respectively. Under random mating the 1st and 3rd components are the most important. The observed changes in gene frequencies are interpreted in the light of previous theoretical work on the stability of equilibria under selection. Large and rapid changes in the genotypic variance result from the generation of linkage disequilibrium under selection; the observed changes are in good agreement with those predicted on theoretical grounds.