An automated voxelized dosimetry tool for radionuclide therapy based on serial quantitative SPECT/CT imaging
An automated voxelized dosimetry tool for radionuclide therapy based on serial quantitative SPECT/CT imaging
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DOI：
10.1118/1.4824318
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发表时间：
2013-11-01
期刊：
影响因子：
3.8
通讯作者：
Hicks, Rodney J.
中科院分区：
文献类型：
--
作者：
Jackson, Price A.;Beauregard, Jean-Mathieu;Hicks, Rodney J.
目的：建立一个准确的地图放射性核素therapeutic.Methods：系列定量SPECT/CT图像采集在4，24，和72小时的28（177）Luoctreotate肽受体放射性核素治疗（PRRT）管理17例晚期神经内分泌肿瘤患者的辐射剂量沉积在健康和靶组织的分布。将可变形图像配准与内部编程算法相结合，以在体素水平上内插药代动力学摄取和清除。所得到的累积活动图像系列由表示每个体素体积内的衰减总数的值组成。对于PRRT，基于Monte Carlo确定的体素S值，在长范围和短范围的组合下，将累积活性转换为吸收剂量。这些剂量测定图像集进行了比较，平均辐射吸收剂量的危险器官使用传统的MIRD协议（OLINDA 1.1）。结果：吸收剂量值的固体器官（肝，肾，脾）使用这两种技术均在10%以内。剂量估计到骨髓更大的使用体素化协议，归因于该软件将从附近的肿瘤volumes.Conclusions交火效应：提出的技术提供了一个有效的，自动化的工具，PRRT剂量测定的基础上，连续治疗后成像。在回顾性分析之后，这种高分辨率剂量测定方法可以允许医生基于个体患者中肿瘤体积所需的剂量或健康组织的辐射限制来规定活动。2013年美国医学物理学家协会。
Purpose: To create an accurate map of the distribution of radiation dose deposition in healthy and target tissues during radionuclide therapy.Methods: Serial quantitative SPECT/CT images were acquired at 4, 24, and 72 h for 28 (177)Luoctreotate peptide receptor radionuclide therapy (PRRT) administrations in 17 patients with advanced neuroendocrine tumors. Deformable image registration was combined with an in-house programming algorithm to interpolate pharmacokinetic uptake and clearance at a voxel level. The resultant cumulated activity image series are comprised of values representing the total number of decays within each voxel's volume. For PRRT, cumulated activity was translated to absorbed dose based on Monte Carlo-determined voxel S-values at a combination of long and short ranges. These dosimetric image sets were compared for mean radiation absorbed dose to at-risk organs using a conventional MIRD protocol (OLINDA 1.1).Results: Absorbed dose values to solid organs (liver, kidneys, and spleen) were within 10% using both techniques. Dose estimates to marrow were greater using the voxelized protocol, attributed to the software incorporating crossfire effect from nearby tumor volumes.Conclusions: The technique presented offers an efficient, automated tool for PRRT dosimetry based on serial post-therapy imaging. Following retrospective analysis, this method of high-resolution dosimetry may allow physicians to prescribe activity based on required dose to tumor volume or radiation limits to healthy tissue in individual patients. 2013 American Association of Physicists in Medicine.