Kinesin-13 and tubulin posttranslational modifications regulate microtubule growth in axon regeneration.
Kinesin-13 and tubulin posttranslational modifications regulate microtubule growth in axon regeneration.
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DOI：
10.1016/j.devcel.2012.08.010
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发表时间：
2012-10-16
影响因子：
11.8
通讯作者：
Chisholm, Andrew D.
中科院分区：
文献类型：
--
作者：
Ghosh-Roy, Anindya;Goncharov, Alexandr;Jin, Yishi;Chisholm, Andrew D.
The microtubule (MT) cytoskeleton of a mature axon is maintained in a stabilized steady state, yet after axonal injury can be transformed into a dynamic structure capable of supporting axon regrowth. Using C. elegans mechanosensory axons and in vivo imaging we find that in mature axons the growth of MTs is restricted in the steady state by the depolymerizing kinesin-13 family member KLP-7. After axon injury, we observe a two-phase process of MT growth upregulation. First, the number of growing MTs increases at the injury site, concomitant with local downregulation of KLP-7. A second phase of persistent MT growth requires the cytosolic carboxypeptidase CCPP-6, which promotes Δ2 modification of α-tubulin. Both phases of MT growth are coordinated by the DLK-1 MAP kinase cascade. Our results define how the stable MT cytoskeleton of a mature neuron is converted into the dynamically growing MT cytoskeleton of a regrowing axon.
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影响因子：
2.5
作者：
Erez, Hadas;Spira, Micha E.
通讯作者：
Spira, Micha E.
影响因子：
16.2
作者：
El Bejjani R;Hammarlund M
通讯作者：
Hammarlund M
影响因子：
9.2
作者：
Bradke, F;Dotti, CG
通讯作者：
Dotti, CG
影响因子：
3.3
作者：
Ems-McClung, Stephanie C.;Hertzer, Kathleen M.;Walczak, Claire E.
通讯作者：
Walczak, Claire E.
DOI：
10.1126/science.1165527
发表时间：
2009-02-06
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Hammarlund M;Nix P;Hauth L;Jorgensen EM;Bastiani M
通讯作者：
Bastiani M