Hydrogen Sulfide-Activatable Second Near-Infrared Fluorescent Nanoassemblies for Targeted Photothermal Cancer Therapy
Hydrogen Sulfide-Activatable Second Near-Infrared Fluorescent Nanoassemblies for Targeted Photothermal Cancer Therapy
复制标题
用于靶向光热癌症治疗的硫化氢可激活第二近红外荧光纳米组件
DOI：
10.1021/acs.nanolett.8b02767
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发表时间：
2018-10-01
期刊：
影响因子：
10.8
通讯作者：
Tian, He
中科院分区：
文献类型：
--
作者：
Shi, Ben;Yan, Qinglong;Tian, He
近红外（NIR）-II荧光剂为癌症的深部组织光热治疗（PTT）带来了巨大的希望，但PTT固有的非特异性和毒性仍然限制了PTT的应用。为了应对这一挑战，我们在此开发了一种硫化氢（H2S）可激活的纳米结构光热剂（Nano-PT），用于结直肠癌（CRC）的位点特异性NIR-II荧光引导的PTT。我们的体内研究表明，这种治疗诊断Nano-PT探针在富含H2S的CRC组织中特异性激活，而在正常组织中无功能。Nano-PT的活化不仅发射具有比常规荧光探针更深的组织穿透能力的NIR-II荧光，而且产生高NIR吸收，从而在NIR激光照射下产生有效的光热转换。重要的是，我们通过在荷瘤小鼠中应用Nano-PT试剂建立了NIR-II成像引导的CRC PTT，从而导致肿瘤完全消退，同时具有最小的非特异性损伤。因此，我们的研究揭示了癌症生物标志物激活的PTT用于精准医学的发展。
Near-infrared (NIR)-II fluorescence agents hold great promise for deep-tissue photothermal therapy (PTT) of cancers, which nevertheless remains restricted by the inherent nonspecificity and toxicity of PTT. In response to this challenge, we herein develop a hydrogen sulfide (H2S)-activatable nanostructured photothermal agent (Nano-PT) for site-specific NIR-II fluorescence-guided PTT of colorectal cancer (CRC). Our in vivo studies reveal that this theranostic Nano-PT probe is specifically activated in H2S-rich CRC tissues, whereas it is nonfunctional in normal tissues. Activation of Nano-PT not only emits NIR-II fluorescence with deeper tissue penetration ability than conventional fluorescent probes but also generates high NIR absorption resulting in efficient photothermal conversion under NIR laser irradiation. Importantly, we establish NIR-II imaging-guided PTT of CRC by applying the Nano-PT agent in tumor-bearing mice, which results in complete tumor regression with minimal nonspecific damages. Our studies thus shed light on the development of cancer biomarker-activated PTT for precision medicine.