Ultrasound driven synthesis of reversed-phase stationary phases for liquid chromatography using 4-dimethyl-aminopyridine as acid-acceptor.
Ultrasound driven synthesis of reversed-phase stationary phases for liquid chromatography using 4-dimethyl-aminopyridine as acid-acceptor.
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DOI：
10.1016/s0021-9673(01)82109-9
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
K. Sentell;K. Barnes;J. Dorsey
中科院分区：
文献类型：
--
作者：
K. Sentell;K. Barnes;J. Dorsey
提出了一种利用超声波作为键合反应驱动力合成高密度单体反相色谱填料的新方法。使用超声波有两个明显的优势，传统的回流方法。它提供了一个独立于温度的反应驱动力;此外，可以使用可变功率超声探头来改变超声驱动力的功率。在键合反应中还推荐使用新型酸受体4-二甲氨基吡啶，因为其易于使用且所得键合密度高。
A reproducible new method for synthesizing high density monomeric reversed-phase chromatographic packings based on the use of ultrasonic waves as the driving force for the bonding reaction is presented. The use of ultrasound has two distinct advantages over traditional reflux methods. It provides a reaction driving force that is independent of temperature; in addition, the power of the ultrasonic driving force can be varied using a variable-power ultrasonic probe. The use of a novel acid-acceptor, 4-dimethylaminopyridine, is also recommended in the bonding reaction due to its ease of use and the resulting high bonding densities.