Biaxial Stress Relaxation of Vaginal Tissue in Pubertal Gilts
Biaxial Stress Relaxation of Vaginal Tissue in Pubertal Gilts
复制标题
青春期后备母猪阴道组织的双轴应力松弛
DOI：
10.1115/1.4045707
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
De Vita, Raffaella
中科院分区：
文献类型：
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作者：
Pack, Erica;Dubik, Justin;Snyder, William;Simon, Alexander;Clark, Sherrie;De Vita, Raffaella
盆腔器官脱垂（POP）是一种以阴道从其正常解剖位置移位为特征的疾病，可导致尿失禁、身体不适和自我形象不佳等症状。保守治疗已显示出有限的成功和外科手术，包括使用补片，往往导致严重的并发症。为了改进目前脱垂的治疗方法，需要对阴道组织的粘弹性特性进行表征。我们测定了从健康的青春期后备母猪分离的阴道组织的双轴应力松弛反应。将侧面沿阴道纵向（LD）和周向（CD）对齐的方形标本（n =20）双向移位5 n。然后在LD和CD中分别以5 N的位移保持20 min，并使用数字图像相关（DIC）测量相应的应变。20 min后，LD和CD的应力分别下降了1和2。LD和CD中的菌株分别从0.080±0.054增加到0.091±0.064和0.050±0.039增加到0.058±0.047，但变化不显著（p < 0.01）。通过使用Peleg模型，发现LD的初始衰减率和应力松弛期间的渐近应力明显高于CD()，表明LD的应力松弛程度更高。这些发现可能对改进当前用于脱垂治疗的手术网格、机械装置和物理治疗具有指导意义。
Pelvic organ prolapse (POP) is a condition characterized by displacement of the vagina from its normal anatomical position leading to symptoms such as incontinence, physical discomfort, and poor self-image. Conservative treatment has shown limited success and surgical procedures, including the use of mesh, often lead to severe complications. To improve the current treatment methods for prolapse, the viscoelastic properties of vaginal tissue need to be characterized. We determined the biaxial stress relaxation response of vaginal tissue isolated from healthy pubertal gilts. Square specimens (n =20) with sides aligned along the longitudinal directions (LD) and circumferential direction (CD) of the vagina were biaxially displaced up to 5 N. The specimens were then kept at the displacements corresponding to 5 N for 20 min in both the LD and CD, and the corresponding strains were measured using digital image correlation (DIC). The stresses in the LD and CD were found to decrease byandafter 20 min, respectively. The strain in the LD and CD increased slightly from 0.080 ± 0.054 to 0.091 ± 0.064 and 0.050 ± 0.039 to 0.058 ± 0.047, respectively, but these changes were not significant (p >0.01). By using the Peleg model, the initial decay rate and the asymptotic stress during stress relaxation were found to be significantly higher in the LD than in the CD (), suggesting higher stress relaxation in the LD. These findings may have implications for improving current surgical mesh, mechanical devices, and physical therapy used for prolapse treatment.