Alterations in male infant behaviors towards its mother by prenatal exposure to bisphenol A in cynomolgus monkeys (Macaca fascicularis) during early suckling period
Alterations in male infant behaviors towards its mother by prenatal exposure to bisphenol A in cynomolgus monkeys (Macaca fascicularis) during early suckling period
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DOI：
10.1016/j.psyneuen.2009.03.005
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发表时间：
2009-09-01
影响因子：
3.7
通讯作者：
Koyama, Takamasa
中科院分区：
文献类型：
--
作者：
Nakagami, Akiko;Negishi, Takayuki;Koyama, Takamasa
双酚A（BPA）是一种具有生理效力的环境化学品，根据对实验啮齿动物的一些研究，即使在与环境相关的暴露下也会造成不良影响。因此，人们越来越关注人类对BPA的环境暴露。在本研究中，我们使用实验控制的食蟹猴（Macaca fascicularis）通过皮下植入泵评估产前暴露于BPA（10 μ g/（kg/天））的影响，并检查哺乳期婴儿和母亲之间的社会行为。从哺乳早期开始，食蟹猴的母婴行为就表现出与婴儿性别相关的性二态性。出生前暴露于BPA显著改变了男婴的行为，BPA暴露的男婴表现为女婴。对女婴的某些行为也有影响。因此，妊娠期BPA暴露改变了母亲的一些行为，主要是在哺乳期母亲中。这些结果表明，BPA暴露影响了交配猴的行为性别分化，这促进了对人类BPA暴露风险的认识。(C)2009爱思唯尔有限公司保留所有权利。
Bisphenol A (BPA) is an environmental chemical with physiological potencies that cause adverse effects, even at environmentally relevant exposures, on the basis of a number of studies in experimental rodents. Thus, there is an increasing concern about environmental exposure of humans to BPA. In the present study, we used experimentally controlled cynomolgus monkeys (Macaca fascicularis) to assess the influence of prenatal exposure to BPA (10 mu g/(kg day)) via subcutaneously implanted pumps and examined social behaviors between infants and their mothers during the suckling period. Mother-infant interactions in cynomolgus monkeys had behavioral sexual dimorphism associated with sex of infant from early suckling period. Prenatal exposure to BPA altered the behaviors of male infants significantly; BPA-exposed male infants behaved as female infants. And it also affected some of female infant behaviors. Consequently, gestational BPA exposure altered some behaviors of their mothers, mainly in mate-nursing mothers. These results suggest that BPA exposure affects behavioral sexual differentiation in mate monkeys, which promotes the understanding of risk of BPA exposure in human. (C) 2009 Elsevier Ltd. All rights reserved.