Detection and Quantitative Evaluation of Lupus Circulating Anticoagulant Activity
Detection and Quantitative Evaluation of Lupus Circulating Anticoagulant Activity
复制标题
狼疮循环抗凝活性的检测和定量评价
DOI：
10.1055/s-0038-1651083
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发表时间：
1987
影响因子：
6.7
通讯作者：
A. Many
中科院分区：
文献类型：
--
作者：
Esther Rosner;R. Pauzner;A. Lusky;M. Modan;A. Many
总结66例SLE患者进行了研究，狼疮型循环抗凝剂的存在。49%的人显示出这种抗凝剂的活性。比较各种凝血试验的敏感性。发现再钙化时间是最敏感的筛选试验，高岭土凝固时间混合物试验是确定抗凝剂存在的最佳方法。组织凝血活酶抑制试验仅能检出半数由白陶土凝固时间和白陶土凝固时间混合试验检出的抗凝物。使用2种不同的试剂，APTT的假阴性率分别为73%和52%。提出了一个确定抗凝剂存在的数值指标及其定量评价。血栓栓塞事件，复发性流产和不同的凝血试验之间的关联。
Summary Sixty-six SLE patients were studied for the presence of lupus type circulating anticoagulant. Forty-nine percent of them showed activity of this anticoagulant. The sensitivity of various coagulation tests was compared. Recalcification time was found to be the most sensitive screening test and the kaolin clotting time mixture test, the best for determining the presence of the anticoagulant. Tissue thromboplastin inhibition test detected only half of the patients in whom the anticoagulant was found by recalcification time and kaolin clotting time mixture test. APTT, using 2 different reagents, resulted in 73% and 52% false negatives. A numerical index for determining the presence of the anticoagulant and its quantitative evaluation is suggested. The association between thromboembolic events, recurrent abortions and the different coagulation tests is shown.