Natural infection of Delta mutant of SARS-CoV-2 in Asiatic lions of India
Natural infection of Delta mutant of SARS-CoV-2 in Asiatic lions of India
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DOI：
10.1111/tbed.14290
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发表时间：
2021-08-26
影响因子：
4.3
通讯作者：
Sharma, G. K.
中科院分区：
文献类型：
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作者：
Karikalan, M.;Chander, V;Sharma, G. K.
当前由新型冠状病毒（SARS-CoV-2）引起的大流行凸显了新出现的人畜共患疾病的重要性。与人类一样，几种野生动物和宠物动物已被证明在自然和实验中感染了 SARS-CoV-2。此外，随着新变异的不断出现，物种的易感性可能会进一步变化，这需要加强筛查工作。印度幅员辽阔，人口第二多，栖息着种类繁多的动物。在这项研究中，我们记录了三只圈养亚洲狮的 SARS-CoV-2 感染情况。详细的基因组特征揭示了 SARS-CoV-2 的 Delta 突变体（Pango 谱系 B.1.617.2）在两个不同位置的参与。有趣的是，没有发现动物园/公园内的其他猫科动物受到感染。流行病学和分子分析将有助于了解野生和家养动物中出现的 SARS-CoV-2 突变体。
The current pandemic caused by a novel coronavirus (SARS-CoV-2) has underlined the importance of emerging diseases of zoonotic importance. Along with human beings, several species of wild and pet animals have been demonstrated to be infected by SARS-CoV-2, both naturally and experimentally. In addition, with constant emergence of new variants, the species susceptibility might further change which warrants intensified screening efforts. India is a vast and second most populated country, with a habitat of a very diverse range of animal species. In this study we place on record of SARS-CoV-2 infections in three captive Asiatic lions. Detailed genomic characterization revealed involvement of Delta mutant (Pango lineage B.1.617.2) of SARS-CoV-2 at two different locations. Interestingly, no other feline species enclosed in the zoo/park were found infected. The epidemiological and molecular analysis will contribute to the understanding of the emerging mutants of SARS-CoV-2 in wild and domestic animals.