Excitation and adaptation in bacteria-a model signal transduction system that controls taxis and spatial pattern formation.
Excitation and adaptation in bacteria-a model signal transduction system that controls taxis and spatial pattern formation.
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DOI：
10.3390/ijms14059205
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发表时间：
2013-04-26
影响因子：
5.6
通讯作者：
Xue C
中科院分区：
文献类型：
--
作者：
Othmer HG;Xin X;Xue C
大肠杆菌中趋化刺激的转导机制是特征最完整的信号转导系统之一，并且由于其相对简单，因此可以对该系统进行定量分析。在这里，我们讨论重现系统许多重要行为的模型。信号转导系统的重要特征是激发和适应，后者意味着转导系统可以作为配体浓度的“衍生传感器”，因为信号的直流分量如果不是太大，最终会被忽略。这种时间传感机制为细菌提供了其通过空间或时间变化的信号场的记忆，而适应对于成功的趋化性至关重要。我们还讨论了在群体中观察到的一些空间模式，并指出了如何将细胞水平的行为嵌入到群体水平的描述中。
The machinery for transduction of chemotactic stimuli in the bacterium E. coli is one of the most completely characterized signal transduction systems, and because of its relative simplicity, quantitative analysis of this system is possible. Here we discuss models which reproduce many of the important behaviors of the system. The important characteristics of the signal transduction system are excitation and adaptation, and the latter implies that the transduction system can function as a “derivative sensor” with respect to the ligand concentration in that the DC component of a signal is ultimately ignored if it is not too large. This temporal sensing mechanism provides the bacterium with a memory of its passage through spatially- or temporally-varying signal fields, and adaptation is essential for successful chemotaxis. We also discuss some of the spatial patterns observed in populations and indicate how cell-level behavior can be embedded in population-level descriptions.
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影响因子：
64.8
作者：
Barkai, N;Leibler, S
通讯作者：
Leibler, S
影响因子：
1.9
作者：
ALT, W
通讯作者：
ALT, W
影响因子：
5.6
作者：
ASAKURA, S;HONDA, H
通讯作者：
HONDA, H
DOI：
10.1073/pnas.1001062107
发表时间：
2010-04-06
影响因子：
11.1
作者：
Be'er, Avraham;Ariel, Gil;Swinney, Harry L.
通讯作者：
Swinney, Harry L.
影响因子：
3.2
作者：
BLOCK, SM;SEGALL, JE;BERG, HC
通讯作者：
BERG, HC