Dietary and reproductive determinants of plasma organochlorine levels in pregnant women in Rio de Janeiro
Dietary and reproductive determinants of plasma organochlorine levels in pregnant women in Rio de Janeiro
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DOI：
10.1016/s0013-9351(02)00053-1
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发表时间：
2003-03-01
影响因子：
8.3
通讯作者：
Wolff, M
中科院分区：
文献类型：
--
作者：
Sarcinelli, PN;Pereira, ACS;Wolff, M
对来自巴西里约热内卢的64名孕妇的血浆有机氯（OC）水平及其饮食和生殖决定因素进行了调查。在这些妇女的一个亚组中对新生儿的产前暴露进行了评估，并对脐带血进行了分析。为了评估饮食因素对OC水平的影响，参与者完成了半定量食物频率问卷。非饮食决定因素进行了调查，通过一般问卷，解决生育史，生活方式和社会人口特征。妇女和她们的新生儿都有可检测到但水平较低的OC。最常检测到的化合物是p，p '-DDE，它是p，p'-DDT的主要代谢物。在97%的参与研究的妇女和67%的脐带血样本中发现了这种化合物，其水平分别为0.161至8.03 ppb和0.320至1.06 ppb。在检测到的OCs中，只有p，p '-DDE与膳食和非膳食因素有相关性。母体p，p '-DDE与鱼（Pearson r = 0.38，P = 0.002）和鸡（Pearson r = 0.26，P = 0.042）的消费量呈正相关。猪肉消费量与p，p-DDE呈负相关（Pearson r =-0.25，P = 0.052）。胎次是唯一显示出显著相关性的非饮食因素（Pearson r =-0.36，P = 0.004）。这组妇女p，p '-DDE水平的主要决定因素是鱼类消费量和产次，共解释了28%的方差（P
Organochlorine (OC) plasma levels and their dietary and reproductive determinants were investigated in 64 pregnant women from Rio de Janeiro, Brazil. Prenatal exposure of newborns was evaluated in a subset of these women in which umbilical cord blood was analyzed. To assess the influence of dietary factors on OC levels, a semiquantitative food frequency questionnaire was completed by participants. Nondietary determinants were investigated through a general questionnaire that addressed reproductive history, lifestyle, and social-demographic characteristics. Both women and their newborns had detectable but low levels of OCs. The most frequently detected compound was p,p'-DDE, the main metabolite of p,p'-DDT. This compound was found in 97% of the women who participated in the study and in 67% of the umbilical cord blood samples, with levels ranging from 0.161 to 8.03 ppb and from 0.320 to 1.06 ppb, respectively. Among the OCs detected, only p,p'-DDE showed any correlation with dietary and nondietary factors. There was a positive correlation between maternal p,p'-DDE and the consumption of fish (Pearson r = 0.38, P = 0.002) and chicken (Pearson r = 0.26, P = 0.042). The correlation between pork consumption and p,p-DDE exhibited an inverse relationship (Pearson r = -0.25, P = 0.052). Parity was the only nondietary factor that showed a significant correlation (Pearson r = -0.36, P = 0.004). The main determinants of p,p'-DDE levels in this group of women were fish consumption and parity, together explaining 28% of the variance (P