An update on renal fibrosis: from mechanisms to therapeutic strategies with a focus on extracellular vesicles.
An update on renal fibrosis: from mechanisms to therapeutic strategies with a focus on extracellular vesicles.
复制标题
肾纤维化的最新进展：从机制到治疗策略，重点关注细胞外囊泡。
DOI：
10.23876/j.krcp.22.159
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发表时间：
2023-03
影响因子：
3
通讯作者：
Lin-Li, Lv
中科院分区：
文献类型：
--
作者：
Cui, Wang;Wei, Li Shang;Xin, Zhong;Bi-Cheng, Liu;Lin-Li, Lv
慢性肾脏病（CKD）的患病率不断增加，是一个主要的全球公共卫生问题。尽管CKD的发病机制复杂，但肾纤维化代表了最常见的病理状况，其包括细胞外基质在患病肾脏中的进行性积累。在过去的几十年里，对肾纤维化机制的认识取得了巨大进展，并出现了针对纤维化相关信号通路的相应潜在治疗策略。重要的是，细胞外囊泡（EV）通过介导细胞通讯而显著促进肾脏炎症和纤维化。越来越多的证据表明基于EV的治疗在肾脏炎症和纤维化中的潜力，这可能代表CKD治疗的未来方向。
The increasing prevalence of chronic kidney disease (CKD) is a major global public health concern. Despite the complicated pathogenesis of CKD, renal fibrosis represents the most common pathological condition, comprised of progressive accumulation of extracellular matrix in the diseased kidney. Over the last several decades, tremendous progress in understanding the mechanism of renal fibrosis has been achieved, and corresponding potential therapeutic strategies targeting fibrosis-related signaling pathways are emerging. Importantly, extracellular vesicles (EVs) contribute significantly to renal inflammation and fibrosis by mediating cellular communication. Increasing evidence suggests the potential of EV-based therapy in renal inflammation and fibrosis, which may represent a future direction for CKD therapy.