Rapid identification of chemical components in Zhizi Baipi decoction by ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry coupled with a novel informatics UNIFI platform
Rapid identification of chemical components in Zhizi Baipi decoction by ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry coupled with a novel informatics UNIFI platform
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DOI：
10.1002/jssc.202200306
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发表时间：
2022-08-21
影响因子：
3.1
通讯作者：
Wang, Xijun
中科院分区：
文献类型：
--
作者：
Wei, Wenfeng;Liu, Shaobo;Wang, Xijun
栀子白皮汤是治疗黄疸及各种肝病的经典中药方剂。由于相关研究的缺乏，栀子白皮汤的化学成分尚不明确，阻碍了其药理机制的阐明和临床上的综合开发利用。本研究采用超高效液相色谱-四极杆-飞行时间质谱联用技术结合UNIFI天然产物信息分析平台对栀子白皮汤中的化学成分进行快速分析鉴定。枳子白皮汤共鉴定出122种化学成分，其中黄酮类化合物53种、生物碱16种、萜类化合物25种、苯丙类化合物5种、有机酸14种、其他7种。这些化合物可能是栀子白皮汤的活性成分。本研究建立的方法能够系统、快速、准确地解析栀子白皮汤中的化学成分，为进一步建立栀子白皮汤的药效物质基础和质量控制奠定基础。
Zhizi Baipi decoction is a classic traditional Chinese medicine formula for the treatment of jaundice and various liver diseases. The chemical components of Zhizi baipi decoction were not clear resulting of the paucity of relevant studies, which hindered the elucidation of the pharmacological mechanism, and the comprehensive development and utilization of Zhizi baipi decoction in clinical. In this study, ultra-performance liquid chromatography-quadrupole-time of flight mass spectrometry combined with the UNIFI natural product information analysis platform was used to rapidly analyze and identify the chemical components in Zhizi baipi decoction. A total of 122 chemical components, including 53 flavonoids, 16 alkaloids, 25 terpenoids, five phenylpropanoids, 14 organic acids, and seven others, were identified from Zhizi baipi decoction. These compounds may be the active components of Zhizi baipi decoction. The method established in this study can systematically, rapidly, and accurately resolve the chemical components in Zhizi baipi decoction, which lays the foundation for further establishment of the pharmacodynamic substance basis and quality control of Zhizi baipi decoction.