Metastasis-associated protein 1 is a novel marker predicting survival and lymph nodes metastasis in cervical cancer
Metastasis-associated protein 1 is a novel marker predicting survival and lymph nodes metastasis in cervical cancer
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转移相关蛋白1是预测宫颈癌生存和淋巴结转移的新标志物
DOI：
10.1016/j.humpath.2013.05.009
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发表时间：
2013-10-01
期刊：
影响因子：
3.3
通讯作者：
Lou, Ge
中科院分区：
文献类型：
--
作者：
Liu, Tianbo;Yang, Ming;Lou, Ge
转移相关基因 1 (MTA1) 参与肿瘤进展、转移和血管生成，已在多种恶性肿瘤中得到检测。然而，MTA1在人宫颈癌中的表达及其作用仍不清楚。本研究探讨MTA1在宫颈癌中的表达水平及其临床意义。通过免疫组织化学染色，在 132 个福尔马林固定、石蜡包埋的宫颈癌组织中分析了 MTA1 过表达与临床特征和患者结果的相关性。 132 名患者中有 73 名 (55.3%) 检测到 MTA1 蛋白过度表达。高水平的 MTA1 蛋白与组织学分级 (P = .006)、淋巴结转移 (P = .001) 和复发 (P = .016) 明显相关。多变量 Cox 分析显示，MTA1 是总生存（风险比，3.486；95% 置信区间 [CI]，1.274-9.537；P = .015）和无病生存（风险比，3.373；95% CI，1.212-9.387；P = .020）的独立因素。多变量逻辑回归分析表明，MTA1 升高与淋巴结转移密切相关（比值比，3.879；95% CI，1.391-10.816；P = .010）。计算出的敏感性和特异性分别为 81.25% 和 53.0%。这些发现表明MTA1核过度表达与肿瘤进展和转移相关，从而支持其在未来基因靶向治疗中的临床意义，特别是宫颈癌患者的治疗。 (c) 2013 Elsevier Inc. 保留所有权利。
Metastasis-associated gene 1 (MTA1), which is involved in tumor progression, metastasis, and angiogenesis, has been examined in several malignant tumors. However, the expression and the effect of MTA1 on human cervical cancer remain unknown. In this study, we investigated the level of MTA1 expression in cervical carcinoma and its clinical significance. By immunohistochemical staining, the correlation of MTA1 overexpression with clinical features and patient outcome was analyzed in 132 formalin-fixed, paraffin-embedded cervical cancer tissues. MTA1 protein overexpression was detected in 73 (55.3%) of 132 patients. High levels of MTA1 protein were clearly correlated with histologic grade (P = .006), lymph node metastasis (P = .001), and recurrence (P = .016). Multivariate Cox analysis showed that MTA1 was an independent factor for overall survival (hazard ratio, 3.486; 95% confidence interval [CI], 1.274-9.537; P = .015) and disease-free survival (hazard ratio, 3.373; 95% CI, 1.212-9.387; P = .020). Multivariate logistic regression analysis indicated that elevated MTA1 was strongly associated with lymph node metastasis (odds ratio, 3.879; 95% CI, 1.391-10.816; P = .010). Sensitivity and specificity were calculated as 81.25% and 53.0%, respectively. These findings suggest that MTA1 nuclear overexpression is associated with tumor progression and metastasis and thus support its clinical significance in future gene-targeted therapies, particularly the management of patients with cervical cancer. (c) 2013 Elsevier Inc. All rights reserved.