HEAD AND TAIL DEVELOPMENT OF THE DROSOPHILA EMBRYO INVOLVES SPALT, A NOVEL HOMEOTIC GENE
HEAD AND TAIL DEVELOPMENT OF THE DROSOPHILA EMBRYO INVOLVES SPALT, A NOVEL HOMEOTIC GENE
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DOI：
10.1002/j.1460-2075.1988.tb02799.x
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发表时间：
1988-01-01
期刊：
影响因子：
11.4
通讯作者：
JURGENS, G
中科院分区：
文献类型：
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作者：
JURGENS, G
果蝇第二条染色体上的一个新的同源异型基因sal突变引起了胚胎两个亚末端区域的相反的转变：头部后部转变为胸部前部结构，尾部前部转变为腹部后部结构。双突变体的胚胎表型为SALAND和不同的双足（ANT‐C）或bithorax（BX‐C）基因表明，salacts独立于后者的基因复合体的层次顺序。导致ANT‐C和BX‐C基因异位表达的反式调节基因突变不会改变salactions的领域。有人提出，thesalgene的区域特异性作用主要促进头部发育，而不是躯干发育，而BX-C基因AbdB区分尾部和头部。
Mutations inspalt (sal), a novel homeotic gene on the second chromosome ofDrosophila, cause opposite transformations in two subterminal regions of the embryo: posterior head segments are transformed into anterior thoracic structures and anterior tail segments are transformed into posterior abdominal structures. The embryonic phenotypes of double mutants forsaland various Antennapedia (ANT‐C) or bithorax (BX‐C) genes indicate thatsalacts independently of the hierarchical order of the latter gene complexes.Trans‐regulatory gene mutations causing ectopic expression of ANT‐C and BX‐C genes do not change the realms ofsalaction. It is proposed that the region‐specific action of thesalgene primarily promotes head as opposed to trunk development, while the BX‐C geneAbdBdistinguishes tail from head.