Time trends in the incidence of type 1 diabetes in Finnish children:: a cohort study
Time trends in the incidence of type 1 diabetes in Finnish children:: a cohort study
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DOI：
10.1016/s0140-6736(08)60765-5
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发表时间：
2008-05-24
期刊：
影响因子：
168.9
通讯作者：
Tuomilehto, Jaakko
中科院分区：
文献类型：
--
作者：
Harjutsalo, Valma;Sjoberg, Lena;Tuomilehto, Jaakko
背景芬兰是世界上1型糖尿病发病率最高的国家，在20世纪90年代达到每年每10万人40例。我们的目的是评估自2000年以来芬兰15岁以下儿童1型糖尿病发病率的时间趋势，并预测未来1型糖尿病的病例数。1980-2005年出院登记表纳入队列研究。我们排除了2型糖尿病和糖尿病发生继发于其他条件，如类固醇的使用，唐氏综合征，先天性畸形pancreat.Findings 10737儿童-5816名男孩和4921名女孩-被诊断为1型糖尿病15岁之前在1980年至2005年。在此期间，平均年龄标准化发病率为每年每10万人42.9例（95%CI 42.6-44.3），从1980年的每年每10万人31.4例增加到2005年的每年每10万人64.2例。每年每10万人的特定年龄比率分别为31.0、50.5和50。0-4岁、5-9岁和10-14岁分别为6例。我们注意到一个显着的非线性组成部分的时间趋势（p
Background Finland has the highest incidence of type 1 diabetes worldwide, reaching 40 per 100000 people per year in the 1990s. Our aim was to assess the temporal trend in type 1 diabetes incidence since 2000 in Finnish children aged younger than 15 years and to predict the number of cases of type 1 diabetes in the future.Methods Children with newly diagnosed type 1 diabetes in Finland who were listed on the National Public Health Institute diabetes register, Central Drug Register, and Hospital Discharge Register in 1980-2005 were included in a cohort study. We excluded patients with type 2 diabetes and diabetes occurring secondary to other conditions, such as steroid use, Down's syndrome, and congenital malformations of pancreas.Findings 10737 children-5816 boys and 4921 girls-were diagnosed with type 1 diabetes before 15 years of age during 1980-2005. The average age-standardised incidence was 42.9 per 100000 per year (95% Cl 42.6-44.3) during this period, increasing from 31.4 per 100 000 per year in 1980 to 64.2 per 100 000 per year in 2005. The age-specific rates per 100 000 per year were 31.0, 50.5, and 50 . 6 at ages 0-4 years, 5-9 years, and 10-14-years, respectively. We noted a significant non-linear component to the time trend (p