Compression and expansion without impulse activity in the retinotectal projection of goldfish.
Compression and expansion without impulse activity in the retinotectal projection of goldfish.
复制标题
金鱼视网膜顶盖投射中无脉冲活动的压缩和扩张。
DOI：
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
L. Wolcott
中科院分区：
文献类型：
--
作者：
R. Meyer;L. Wolcott
再生的光纤进行retinotopic压缩和扩张的冲动活动的情况下，通过定期眼内注射河豚毒素（TTX）再生过程中消除活动的能力进行了测试。为了测试压迫，顶盖的后半部分被移除，视神经被压碎。为了扩张，视网膜的颞侧半部被消融，神经也被压碎。然后用电生理标测和放射自显影追踪检查投影。像电活性纤维，沉默的纤维形成了一个retinotopically有序的投影，被压缩到前半顶盖。同样，TTX处理的纤维从鼻侧半视网膜形成了一个retinotopic投影，扩展到整个顶盖。除了TTX产生的感受野有所扩大外，其地形与活性纤维形成的地形相当。因此，纤维可以明显地保持相对位置，无论绝对顶盖位置没有活动依赖的排序的好处。这意味着存在一个独立于活动的相对定位机制，可以在更大的距离比活动依赖的排序负责精细地形和眼优势列。
The capacity of regenerating optic fibers to undergo retinotopic compression and expansion in the absence of impulse activity was tested by eliminating activity with periodic intraocular injections of tetrodotoxin (TTX) during regeneration. To test for compression, the posterior half of tectum was removed and the optic nerve crushed. For expansion, the temporal half of retina was ablated and the nerve also crushed. The projection was then subsequently examined with electrophysiological mapping and autoradiographic tracing. Like electrically active fibers, silent fibers formed a retinotopically ordered projection that was compressed onto the anterior half tectum. Similarly, TTX-treated fibers from a nasal half retina formed a retinotopic projection that was expanded across the entire tectum. Except for some enlargement of receptive fields produced by the TTX, the topography was equivalent to that formed by active fibers. Thus, fibers can apparently maintain relative positions irrespective of absolute tectal position without the benefit of activity-dependent ordering. This implies the existence of an activity-independent mechanism for relative positioning that may operate across larger distances than the activity-dependent ordering responsible for fine topography and ocular dominance columns.
金鱼偏转光纤导致的眼优势柱的生长和形成。
影响因子：
2.9
作者：
Meyer,RL
通讯作者：
Meyer,RL