Models of spatial and orientational self-organization of microtubules under the influence of gravitational fields.
Models of spatial and orientational self-organization of microtubules under the influence of gravitational fields.
复制标题
引力场影响下微管的空间和方向自组织模型。
DOI：
--
复制
发表时间：
2003
期刊：
影响因子：
--
通讯作者：
M. Sataric
中科院分区：
文献类型：
--
作者：
Stéphanie Portet;J. Tuszynski;J. Dixon;M. Sataric
[答案]C。Papaseit， N. Pochon和J. Tabony, Proc. Natl。学会科学。[U.S.A. 97, 8364(2000)]表明，纯化微管蛋白溶液的微管自组织对重力条件很敏感。本文提出了引力场中微管的空间和方向自组织模型。首先，空间模型是基于主导化学动力学。微管浓度的模式形成是(1)当拆卸速率可以忽略不计时，在极限情况下的移动扭结，以及(2)在没有自由微管蛋白和只有组装的微管存在的情况下。其次，条纹微管畴的取向模式与现象朗道-金兹堡自由能展开在取向序参数方面的预测一致。
Tabony and co-workers [C. Papaseit, N. Pochon, and J. Tabony, Proc. Natl. Acad. Sci. U.S.A. 97, 8364 (2000)] showed that the self-organization of microtubules from purified tubulin solutions is sensitive to gravitational conditions. In this paper, we propose two models of spatial and orientational self-organization of microtubules in a gravitational field. First, the spatial model is based on the dominant chemical kinetics. The pattern formation of microtubule concentration is obtained (1) in terms of a moving kink in the limit when the disassembly rate is negligible, and (2) for the case of no free tubulin and only assembled microtubules present. Second, the orientational pattern of striped microtubule domains is consistent with predictions from a phenomenological Landau-Ginzburg free energy expansion in terms of an orientational order parameter.